Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXRα through structure-based virtual screening.
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DOI: 10.1016/j.bioorg.2019.01.007
Abstract: Retinoid X receptor alpha (RXRα), a central member of the nuclear receptor superfamily and a key regulator of many signal transduction pathways, has been an attractive drug target. We previously discovered that an N-terminally truncated… read more here.
Keywords: tetramer stabilizer; screening; atorvastatin; nuclear receptor ... See more keywords