Unveiling the enzymatic activity of a dimeric LDH isoform and its implications for allosteric inhibition strategies
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DOI: 10.1002/pro.70367
Abstract: Lactate dehydrogenase (LDH) is a key enzyme in cancer metabolism, with isoforms LDH5 and LDH1 supporting glycolysis and oxidative lactate metabolism, respectively. While the development of competitive LDH inhibitors has faced diverse challenges, allosteric strategies… read more here.
Keywords: ldh; tetramerization; unveiling enzymatic; activity ... See more keywords