The protective role of tetramethylpyrazine against cisplatin-induced ototoxicity.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2017.01.005
Abstract: OBJECTIVES The aim of the present study was to investigate the protective effect of tetramethylpyrazine (TMP) on cisplatin-induced ototoxicity in rats. METHODS Forty healthy, female, 24-week-old, Sprague-Dawley rats (n = 40) were randomly assigned to four groups… read more here.
Keywords: cisplatin; group; induced ototoxicity; ototoxicity ... See more keywords
Tetramethylpyrazine blocks TFAM degradation and up-regulates mitochondrial DNA copy number by interacting with TFAM
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20170319
Abstract: The natural small molecule compound: 2,3,5,6-tetramethylpyrazine (TMP), is a major component of the Chinese medicine Chuanxiong, which has wide clinical applications in dilating blood vessels, inhibiting platelet aggregation and treating thrombosis. Recent work suggests that… read more here.
Keywords: lon; degradation; dna; tetramethylpyrazine ... See more keywords
Molecular Mechanism of Tetramethylpyrazine Ameliorating Neuroexcitotoxicity through Activating the PKA/CREB Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/2812839
Abstract: Background Excitotoxicity plays a key role in nervous system disease and can trigger a critical cascade of reaction which affects cell viability and promotes neuronal death. Tetramethylpyrazine (TMP) reveals its effect in the treatment of… read more here.
Keywords: signaling pathway; tetramethylpyrazine; pka creb; concentration ... See more keywords
Intra-Articular Injection of a Nanosuspension of Tetramethylpyrazine Dihydroxynaphthalenate for Stronger and Longer-Lasting Effects Against Osteoarthritis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2021.3094
Abstract: Tetramethylpyrazine (TMP), isolated from the rhizome of the traditional Chinese medicinal plant Chuanxiong (Ligusticum wallichii Franchat) shows therapeutic efficacy against osteoarthritis. After intra-articular injection, the retention time of TMP in the joint cavity is short,… read more here.
Keywords: nanosuspension; tetramethylpyrazine; articular injection; tmp ... See more keywords
A Green Route for High-Yield Production of Tetramethylpyrazine From Non-Food Raw Materials
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.792023
Abstract: 2,3,5,6-Tetramethylpyrazine (TMP) is an active pharmaceutical ingredient originally isolated from Ligusticum wallichii for curing cardiovascular and cerebrovascular diseases and is widely used as a popular flavoring additive in the food industry. Hence, there is a… read more here.
Keywords: raw materials; tetramethylpyrazine; food; production ... See more keywords
Magnetic Resonance Imaging Investigation of Neuroplasticity After Ischemic Stroke in Tetramethylpyrazine-Treated Rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.851746
Abstract: Ischemic stroke elicits white matter injury typically signed by axonal disintegration and demyelination; thus, the development of white matter reorganization is needed. 2,3,5,6-Tetramethylpyrazine (TMP) is widely used to treat ischemic stroke. This study was aimed… read more here.
Keywords: magnetic resonance; matter; resonance imaging; tetramethylpyrazine ... See more keywords
Production of Tetramethylpyrazine from Cane Molasses by Bacillus sp. TTMP20
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062640
Abstract: 2,3,5,6-Tetramethylpyrazine (TTMP) is an active ingredient of Ligusticum wallichii Franch. It can be used in medicine and food fields. In this study, Bacillus sp. TTMP20 was applied to produce TTMP using cane molasses as a… read more here.
Keywords: cane molasses; tetramethylpyrazine; production; ttmp ... See more keywords
Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF-1α and apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.11378
Abstract: The aim of the present study was to investigate the protective effect and underlying mechanism of tetramethylpyrazine (TMP) on renal ischemia reperfusion injury (RIRI) in rats, which refers to the injury caused by the restoration… read more here.
Keywords: renal tissues; group; tmp group; tetramethylpyrazine ... See more keywords