Mechanistic studies of the apoptosis induced by the macrocyclic natural product tetrandrine in MGC 803 cells
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2268-8
Abstract: Tetrandrine (Tet) is a macrocyclic tetrahydroisoquinoline alkaloid isolated from Stephania tetrandra S. Moore along with other Chinese and Japanese herbs. It has been used extensively for the treatment of silicosis, autoimmune disorders, inflammatory diseases and… read more here.
Keywords: mgc 803; gastric cancer; tetrandrine; tet ... See more keywords
Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173575
Abstract: MS-275 (Entinostat), is an oral histone deacetylase (HDAC) inhibitor with a high specificity for class 1 HDACs. As single agent, MS-275 exerts only modest antitumor activity against most solid malignancies. The use of MS-275 in… read more here.
Keywords: bax p53; histone deacetylase; antitumor effects; tetrandrine ... See more keywords
Tetrandrine ameliorated atherosclerosis in vitamin D3/high cholesterol diet-challenged rats via modulation of miR-34a and Wnt5a/Ror2/ABCA1/NF-kB trajectory
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-70872-y
Abstract: Atherosclerosis (AS) is a major cause of cardiovascular diseases that may lead to mortality. This study aimed to evaluate the therapeutic potential of tetrandrine in high cholesterol diet (HCD)-induced atherosclerosis, in rats, via modulation of… read more here.
Keywords: tetrandrine; atherosclerosis; wnt5a ror2; ror2 abca1 ... See more keywords
Tetrandrine-induced downregulation of lncRNA NEAT1 inhibits rheumatoid arthritis progression through the STAT3/miR-17-5p pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2092748
Abstract: Abstract Background The inhibitory effect of Tetrandrine (Tet) on rheumatoid arthritis (RA) is well established. However, its exact molecular mechanism remains unknown. Methods RT-qPCR coupled with western blotting was employed to analyze the expression of… read more here.
Keywords: tetrandrine; rheumatoid arthritis; stat3; expression ... See more keywords
Tetrandrine, an immunosuppressive alkaloid isolated from Steohania tetrandra S. Moore, induces the generation of Treg cells through enhancing fatty acid oxidation
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13500
Abstract: Our previous studies have demonstrated that tetrandrine can induce the generation of regulatory T (Treg) cells in vitro and in vivo. But, the underlying mechanism of tetrandrine remains obscure. Naïve CD4+ T cells are isolated… read more here.
Keywords: treg; treg cells; tetrandrine; acid oxidation ... See more keywords
Tetrandrine induces muscle atrophy involving ROS-mediated inhibition of Akt and FoxO3
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine"
DOI: 10.1186/s10020-024-00981-x
Abstract: Tetrandrine (Tet), a well-known drug of calcium channel blocker, has been broadly applied for anti-inflammatory and anti-fibrogenetic therapy. However, due to the functional diversity of ubiquitous calcium channels, potential side-effects may be expected. Our previous… read more here.
Keywords: tetrandrine; muscle; muscle atrophy; protein degradation ... See more keywords
The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Cell International"
DOI: 10.1186/s12935-017-0410-1
Abstract: BackgroundNon-small cell lung cancer comprises the majority of lung cancer cases and is insensitive to chemotherapy. Most patients develop drug resistance. Recently, tetrandrine (TET), a bis-benzylisoquinoline alkaloid, was identified as a novel anti-cancer agent. However,… read more here.
Keywords: apoptosis; a549; cisplatin; proliferation ... See more keywords
Tetrandrine Enhances Radiosensitization in Human Hepatocellular Carcinoma Cell Lines
Sign Up to like & getrecommendations! Published in 2018 at "Radiation Research"
DOI: 10.1667/rr14981.1
Abstract: The goal of this study was to determine whether tetrandrine enhanced radiosensitization in different hepatocellular carcinoma cell lines and to elucidate the potential mechanism. We also tested whether PA28γ was regulated by tetrandrine. The human… read more here.
Keywords: hepatocellular carcinoma; carcinoma cell; cell lines; dosage tetrandrine ... See more keywords
UNSUCCESSFUL DELIVERY OF TETRANDRINE FROM COLON-TARGETED DOSAGE FORMS COMPRISING ALGINATE/HYDROXYPROPYL METHYLCELLULOSE AND ALGINATE–CHITOSAN BEADS
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2018.v10s1.88
Abstract: Objective: The objective of this study was to optimize the formulations of antifibrotic tetrandrine beads using alginate and various concentrations ofhydroxypropyl methylcellulose (HPMC) and chitosan.Methods: Beads were formulated with six (F1–F6) concentrations of polymer and… read more here.
Keywords: targeted dosage; tetrandrine; colon targeted; dosage forms ... See more keywords
Synergistic Activity of Tetrandrine and Colistin against mcr-1-Harboring Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11101346
Abstract: Before the emergence of plasmid-mediated colistin resistance, colistin was once considered the last drug of choice for infections caused by carbapenem-resistant bacteria. Currently, researchers are relentlessly exploring possible alternative therapies that could efficiently curb the… read more here.
Keywords: tetrandrine; activity tetrandrine; colistin; mcr harboring ... See more keywords
Nano–Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti–Tumor Effects
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126858
Abstract: (1) Background: Curcumin (CUR) and tetrandrine (TET) are natural compounds with various bioactivities, but have problems with low solubility, stability, and absorption rate, resulting in low bioavailability, and limited applications in food, medicine, and other… read more here.
Keywords: anti tumor; nano liposomes; tumor effects; solubility ... See more keywords