Cytoplasmic ends of tetraspanin 7 harbour epitopes recognised by autoantibodies in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-4832-2
Abstract: Aims/hypothesisThe beta cell protein tetraspanin 7 is a target of autoantibodies in individuals with type 1 diabetes. The aim of this study was to identify autoantibody epitope-containing regions and key residues for autoantibody binding.MethodsAutoantibody epitope… read more here.
Keywords: ends tetraspanin; tetraspanin; autoantibody binding; type diabetes ... See more keywords
Tetraspanin 13 Enhances Immune Evasion in Breast Cancer by Promoting MHC-I Degradation.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-25-1223
Abstract: In contrast to highly immunogenic malignancies, breast cancer frequently features a "cold" tumor immune microenvironment marked by low immune cell infiltration and limited activation of effector T cells. This immunosuppressive phenotype poses a substantial barrier… read more here.
Keywords: cancer; breast cancer; degradation; tumor ... See more keywords
Differential tetraspanin genes expression and subcellular localization during mutualistic interactions in Phaseolus vulgaris
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0219765
Abstract: Arbuscular mycorrhizal fungi and rhizobia association with plants are two of the most successful plant-microbe associations that allow the assimilation of P and N by plants, respectively. These mutualistic interactions require a molecular dialogue, i.e.,… read more here.
Keywords: tetraspanin; mutualistic interactions; plant; subcellular localization ... See more keywords
Exosomal tetraspanins mediate cancer metastasis by altering host microenvironment
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19119
Abstract: The metastases of malignant tumors develop through a cascade of events. The establishment of a pre-metastatic micro-environment is initiated by communication between tumors and host. Exosomes come into focus as the most potent intercellular communicators… read more here.
Keywords: tetraspanin; pre metastatic; exosomal tetraspanin; cancer metastasis ... See more keywords
Targeting of Tetraspanin CD81 with Monoclonal Antibodies and Small Molecules to Combat Cancers and Viral Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15072186
Abstract: Simple Summary Novel therapeutic targets are needed to improve treatments of aggressive cancers and viral diseases. Tetraspanins represent an emerging class of anticancer targets, notably the transmembrane protein CD81 which has been structurally well characterized.… read more here.
Keywords: cd81; cancers viral; viral diseases; cd81 monoclonal ... See more keywords
Specific Interaction of DARPin with HIV-1 CANTD Disturbs the Distribution of Gag, RNA Packaging, and Tetraspanin Remodelling in the Membrane
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040824
Abstract: A designed repeat scaffold protein (AnkGAG1D4) recognizing the human immunodeficiency virus-1 (HIV-1) capsid (CA) was formerly established with antiviral assembly. Here, we investigated the molecular mechanism of AnkGAG1D4 function during the late stages of the… read more here.
Keywords: gag; membrane; hiv; specific interaction ... See more keywords
Expression and function of tetraspanin 1 in esophageal carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.7028
Abstract: The present study explored the expression of tetraspanin 1 (TSPAN1) in esophageal carcinoma (EC) and its association with clinicopathological factors. TSPAN1 small interfering RNA (siRNA) was designed to target the TSPAN1 gene in Eca-109 cells… read more here.
Keywords: esophageal carcinoma; tspan1; expression; tetraspanin ... See more keywords