Rhodium-Catalyzed Three-Component Reaction of Alkynes, Arylzinc Chlorides, and Iodomethanes Producing Trisubstituted/Tetrasubstituted Alkenes with/without 1,4-Migration.
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DOI: 10.1021/acs.orglett.2c02299
Abstract: A three-component reaction of alkynes, arylzinc chlorides, and iodomethanes was found to proceed in the presence of a rhodium catalyst to give high yields of trisubstituted/tetrasubstituted alkenes. The usual arylzinc chlorides only gave trisubstituted alkenes,… read more here.
Keywords: arylzinc chlorides; reaction alkynes; component reaction; migration ... See more keywords
Photoredox-Catalyzed C-H Arylation of Internal Alkenes to Tetrasubstituted Alkenes: Synthesis of Tamoxifen.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03223
Abstract: Visible-light-induced direct C-H arylation of S,S-functionalized internal alkenes, that is, α-oxo ketene dithioacetals and analogues, has been efficiently realized with aryldiazonium salts (ArN2BF4) as coupling partners and Ru(bpy)3Cl2·6H2O as photosensitizer at ambient temperature. The strategy… read more here.
Keywords: tetrasubstituted alkenes; photoredox catalyzed; arylation; tamoxifen ... See more keywords
Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates
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DOI: 10.1021/acsomega.8b02966
Abstract: An operationally simple, efficient, and metal-/peroxide-free three-component reaction of alkynes, iodine, and sodium sulfinates has been developed for the construction of highly functionalized tetrasubstituted alkenes. Iodo- and sulfonyl-containing tetrasubstituted alkenes, such as vinyl ketones, allylic… read more here.
Keywords: tetrasubstituted alkenes; iodine sodium; reaction alkynes; alkynes iodine ... See more keywords