Electrochemical Tandem Self‐Coupling/Selenylation of Acetonitrile toward Highly Functionalized Tetrasubstituted Alkenes
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500611
Abstract: Herein, an electrochemical tandem reaction that integrates acetonitrile self‐coupling with selenylation to construct densely functionalized tetrasubstituted alkenes bearing amino, cyano, and seleno groups from readily available acetonitrile and diselenides is reported. Employing potassium iodide as… read more here.
Keywords: functionalized tetrasubstituted; electrochemical tandem; self coupling; coupling selenylation ... See more keywords
Rhodium-Catalyzed Three-Component Reaction of Alkynes, Arylzinc Chlorides, and Iodomethanes Producing Trisubstituted/Tetrasubstituted Alkenes with/without 1,4-Migration.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02299
Abstract: A three-component reaction of alkynes, arylzinc chlorides, and iodomethanes was found to proceed in the presence of a rhodium catalyst to give high yields of trisubstituted/tetrasubstituted alkenes. The usual arylzinc chlorides only gave trisubstituted alkenes,… read more here.
Keywords: arylzinc chlorides; reaction alkynes; component reaction; migration ... See more keywords
Synthesis of Tetrasubstituted Alkenes by Rhodium-Catalyzed Regioselective Cyano Transfer.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c00747
Abstract: We describe herein a novel, general, and robust approach to structurally diversified alkenyl nitriles through a Rh-catalyzed cyano transfer reaction between alkynyl-malononitrile derivatives and aryl/alkenyl boronic acids. This reaction exhibits high chemo- and regioselectivity and… read more here.
Keywords: alkenes rhodium; synthesis tetrasubstituted; cyano transfer; tetrasubstituted alkenes ... See more keywords
Photoredox-Catalyzed C-H Arylation of Internal Alkenes to Tetrasubstituted Alkenes: Synthesis of Tamoxifen.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03223
Abstract: Visible-light-induced direct C-H arylation of S,S-functionalized internal alkenes, that is, α-oxo ketene dithioacetals and analogues, has been efficiently realized with aryldiazonium salts (ArN2BF4) as coupling partners and Ru(bpy)3Cl2·6H2O as photosensitizer at ambient temperature. The strategy… read more here.
Keywords: tetrasubstituted alkenes; photoredox catalyzed; arylation; tamoxifen ... See more keywords
Metal-Free Synthesis of Functionalized Tetrasubstituted Alkenes by Three-Component Reaction of Alkynes, Iodine, and Sodium Sulfinates
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b02966
Abstract: An operationally simple, efficient, and metal-/peroxide-free three-component reaction of alkynes, iodine, and sodium sulfinates has been developed for the construction of highly functionalized tetrasubstituted alkenes. Iodo- and sulfonyl-containing tetrasubstituted alkenes, such as vinyl ketones, allylic… read more here.
Keywords: tetrasubstituted alkenes; iodine sodium; reaction alkynes; alkynes iodine ... See more keywords