Halotrifluoromethylation of 1,3-Enynes: Access to Tetrasubstituted Allenes.
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DOI: 10.1021/acs.orglett.1c00449
Abstract: A highly regioselective copper-catalyzed 1,4-chloro- and bromotrifluoromethylation of 1,3-enynes has been presented for the first time, which affords an efficient transformation to access halo- and CF3-containing tetrasubstituted allene derivatives with good to excellent yield. This… read more here.
Keywords: enynes access; tetrasubstituted allenes; halotrifluoromethylation enynes; access tetrasubstituted ... See more keywords