Palladium-Catalyzed Stereoselective Hydrodefluorination of Tetrasubstituted gem-Difluoroalkenes.
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DOI: 10.1021/acs.orglett.0c01813
Abstract: A highly stereoselective palladium(0)-catalyzed hydrodefluorination (HDF) of tetrasubstituted gem-difluoroalkenes is developed. By using catalytic Pd(PPh3)4 (2.5-5 mol %) and hydrosilane Me2PhSiH, various trisubstituted terminal (E)-monofluoroalkenes can be synthesized with excellent E/Z selectivity (>99:1) and good… read more here.
Keywords: tetrasubstituted gem; catalyzed stereoselective; gem difluoroalkenes; palladium catalyzed ... See more keywords
Highly Selective C-F Bond Functionalization of Tetrasubstituted gem-Difluoroalkenes and Trisubstituted Monofluoroalkenes Using Grignard Reagents.
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DOI: 10.1021/acs.orglett.2c01639
Abstract: We herein describe selective C-F bond functionalizations of tetrasubstituted gem-difluoroalkenes and trisubstituted monofluoroalkenes using Grignard reagents without the transition metal catalyst. β,β-Difluoroacrylates react with Grignard reagents under mild conditions to afford tetrasubstituted (E)-β-monofluoroacrylates. Experimental and… read more here.
Keywords: difluoroalkenes trisubstituted; grignard reagents; tetrasubstituted gem; gem difluoroalkenes ... See more keywords