Articles with "tetrasubstituted phthalans" as a keyword



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Synthesis of 1,1,4,5-Tetrasubstituted Phthalans via Pd-Catalyzed Three-Component Reactions of Haloarenes, Alkynes, and Protic Nucleophiles.

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Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c03460

Abstract: A novel approach for the synthesis of 1,1,4,5-tetrasubstituted phthalans is developed via a tandem palladium-catalyzed Sonogashira coupling/propargyl-allenyl isomerization/pentadehydro-Diels-Alder cyclization/regioselective nucleophilic addition sequence. The reaction shows good functional tolerance and provides a wide variety of substituted… read more here.

Keywords: phthalans via; tetrasubstituted phthalans; synthesis tetrasubstituted; via catalyzed ... See more keywords