Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3.
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DOI: 10.1021/acs.jmedchem.6b01180
Abstract: The concept of covalent inhibition of c-Jun N-terminal kinase 3 (JNK3) was successfully transferred to our well validated pyridinylimidazole scaffold varying several structural features in order to deduce crucial structure-activity relationships. Joint targeting of the… read more here.
Keywords: pyridinylimidazoles covalent; jun terminal; tri tetrasubstituted; tetrasubstituted pyridinylimidazoles ... See more keywords