One-pot multicomponent synthesis of 1,2,3,4-tetrasubstituted pyrroles catalyzed by [NMPH]CH3SO3
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DOI: 10.1016/j.tetlet.2019.151043
Abstract: Abstract A general method for the synthesis of 1,2,3,4-tetrasubstituted pyrroles by [NMPH]CH3SO3 is reported. A full factorial design was performed in order to obtain a more robust and statistically correct optimum condition. The products were… read more here.
Keywords: tetrasubstituted pyrroles; pot multicomponent; synthesis tetrasubstituted; nmph ch3so3 ... See more keywords
Synthesis of unsymmetrically tetrasubstituted pyrroles and studies of AIEE in pyrrolo[1,2-a]pyrimidine derivatives
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DOI: 10.1039/d2sc00837h
Abstract: Pyrroles are among the most important heterocycles in pharmaceuticals and agrochemicals. Construction of pyrrole scaffolds with different substituents and a free NH group, however, is challenging. Herein, a metal-free method for the synthesis of unsymmetrically… read more here.
Keywords: unsymmetrically tetrasubstituted; studies aiee; tetrasubstituted pyrroles; aiee pyrrolo ... See more keywords
A solvent and transition metal-free, highly efficient Brønsted acidic ionic liquid promoted one-potthree-component reactions for the synthesis of tetrasubstituted pyrroles
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1593460
Abstract: Abstract The present protocol describes a highly efficient, transition metal and solvent-free one-pot annulation of amines, dialkyl acetylenedicarboxylates and β-nitrostyrene using imidazolium Brønsted acidic ionic liquid for the synthesis of tetrasubstituted pyrroles. A diverse functionalized… read more here.
Keywords: ionic liquid; nsted acidic; transition metal; tetrasubstituted pyrroles ... See more keywords