Removal of a consensus proline is not sufficient to allow tetratricopeptide repeat oligomerization
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3234
Abstract: Tetratricopeptide repeat (TPR) domains are ubiquitous protein interaction domains that adopt a modular antiparallel array of α‐helices. The TPR fold typically adopts a monomeric state, and consensus TPRs sequences successfully fold into the expected monomeric… read more here.
Keywords: tetratricopeptide repeat; tpr; consensus proline; consensus ... See more keywords
Tetratricopeptide repeat domain 3 overexpression tends to form aggregates and inhibit ubiquitination and degradation of DNA polymerase γ
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22476
Abstract: Tetratricopeptide repeat (TPR) domain 3 (TTC3) is a protein that contains canonical RING finger and TPR motifs. It is encoded by the TTC3 gene located in the Down syndrome critical region (DSCR). In this study,… read more here.
Keywords: degradation; tetratricopeptide repeat; dna polymerase; ttc3 ... See more keywords
Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.63044.13932
Abstract: Objective(s): The involvement of tetratricopeptide repeat domain 9A (TTC9A) in anxiety-like behaviors through estrogen action has been reported in female mice, this study further investigated its effects on social anxiety and aggressive behaviors. Materials and… read more here.
Keywords: female mice; tetratricopeptide repeat; repeat domain; social anxiety ... See more keywords
Novel Mutations of the Tetratricopeptide Repeat Domain 7A Gene and Phenotype/Genotype Comparison
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01066
Abstract: The gastrointestinal tract contains the largest lymphoid organ to react with pathogenic microorganisms and suppress excess inflammation. Patients with primary immunodeficiency diseases (PIDs) can suffer from refractory diarrhea. In this study, we present two siblings… read more here.
Keywords: exon alleles; tetratricopeptide repeat; mia; refractory diarrhea ... See more keywords