Fed-batch production assessment of a tetravalent bispecific antibody: a case study on piggyBac stably transfected HEK293 cells.
Sign Up to like & getrecommendations! Published in 2021 at "New biotechnology"
DOI: 10.1016/j.nbt.2021.07.002
Abstract: The transition from preclinical biological drug development into clinical trials requires an efficient upscaling process. In this context, bispecific antibody drugs are particularly challenging due to their propensity to form aggregates and generally produce low… read more here.
Keywords: bispecific antibody; antibody; fed batch; tetravalent bispecific ... See more keywords
EGFR/CD16A tetravalent bispecific antibody AFM24 to engage NK-cells to kill EGFR expressing tumor cells and safety results in cynomolgus monkey studies.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e14001
Abstract: e14001Background: The epidermal growth factor receptor is a target for the treatment of solid tumors, like CRC, HNSCC and NSCLC. Therapeutic success of EGFR-targeting agents depends on mutations de... read more here.
Keywords: antibody afm24; cd16a tetravalent; egfr cd16a; afm24 engage ... See more keywords