Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3,6-disubstituted-1,2,4,5-tetrazine derivatives as potential antitumor agents
Sign Up to like & getrecommendations! Published in 2019 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2017.04.002
Abstract: Abstract We synthesized two new series of 3-substituted-6-(2,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazines and analysed them for a potential role as antitumor agents. Twenty-two compounds were obtained, and four molecular structures were determined by X-ray diffraction analysis. Using flow cytometry… read more here.
Keywords: tetrazine derivatives; qsar analysis; cell; analysis ... See more keywords
Novel Conjugated s-Tetrazine Derivatives Bearing a 4H-1,2,4-Triazole Scaffold: Synthesis and Luminescent Properties
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DOI: 10.3390/molecules27020459
Abstract: A series of new symmetrical s-tetrazine derivatives, coupled via a 1,4-phenylene linkage with a 4H-1,2,4-triazole ring, were obtained. The combination of these two rings in an extensively coupled system has significant potential applications, mainly in… read more here.
Keywords: novel conjugated; tetrazine derivatives; conjugated tetrazine; luminescent properties ... See more keywords
Synthesis and Luminescent Properties of s-Tetrazine Derivatives Conjugated with the 4H-1,2,4-Triazole Ring
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DOI: 10.3390/molecules27113642
Abstract: New derivatives obtained by the combination of unique 1,2,4,5-tetrazine and 4H-1,2,4-triazole rings have great application potential in many fields. Therefore, two synthetic few-step methodologies, which make use of commercially available 4-cyanobenzoic acid (method A) and… read more here.
Keywords: derivatives conjugated; properties tetrazine; luminescent; synthesis luminescent ... See more keywords