Tunable Synthesis of Hydrogel Microfibers via Interfacial Tetrazine Ligation.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00504
Abstract: Crosslinked, degradable, and cell-adhesive hydrogel microfibers were synthesized via interfacial polymerization employing tetrazine ligation, an exceptionally fast bioorthogonal reaction between strained trans-cyclooctene (TCO) and s-tetrazine (Tz). A hydrophobic trisTCO crosslinker and homo-difunctional poly(ethylene glycol) (PEG)-based… read more here.
Keywords: via interfacial; hydrogel; hydrogel microfibers; tetrazine ligation ... See more keywords
Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01177
Abstract: Activatable cyclopropenes are unreactive toward their inverse electron demand Diels-Alder reaction partner (e.g., s-tetrazines) until they are activated. The activation strategy is highly modular due to the cyclopropene's ability to be caged by various light-… read more here.
Keywords: caged cyclopropenes; tetrazine ligation; ligation; ligation kinetics ... See more keywords
Norbornene-tetrazine ligation chemistry for controlling RNA-guided CRISPR systems
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DOI: 10.1039/d2sc02635j
Abstract: In the present study, norbornene-tetrazine ligation chemistry is harnessed for developing clickable RNA switches in biological contexts. This RNA control strategy is explored with a variety of applications. We further demonstrate the application of RNA-based… read more here.
Keywords: norbornene tetrazine; chemistry; rna; tetrazine ligation ... See more keywords
Recent Advances in the Development of Tetrazine Ligation Tools for Pretargeted Nuclear Imaging
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15060685
Abstract: Tetrazine ligation has gained interest as a bio-orthogonal chemistry tool within the last decade. In nuclear medicine, tetrazine ligation is currently being explored for pretargeted approaches, which have the potential to revolutionize state-of-the-art theranostic strategies.… read more here.
Keywords: development tetrazine; ligation; advances development; tetrazine ligation ... See more keywords