Design, synthesis and biological activity of tetrazole-bearing uric acid transporter 1 inhibitors
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DOI: 10.1007/s40242-017-6351-3
Abstract: Systematic structure-activity relationship(SAR) exploration of a moderately active tetrazole-bearing lesinurad-based hit 1f led to the discovery of a potent uric acid transporter 1(URAT1) inhibitor 1i, which possessed a novel molecular skeleton and was 11-fold more… read more here.
Keywords: uric acid; acid transporter; activity; tetrazole bearing ... See more keywords