Between Protein Fold and Nucleophile Identity: Multiscale Modeling of the TEV Protease Enzyme–Substrate Complex
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05201
Abstract: The cysteine protease from the tobacco etch virus (TEVp) is a well-known and widely utilized enzyme. TEVp’s chymotrypsin-like fold is generally associated with serine catalytic triads that differ in terms of a reaction mechanism from… read more here.
Keywords: nucleophile identity; tevp; protease; multiscale modeling ... See more keywords
Construction, investigation and application of the TEV protease variants with the improved oxidative stability.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.2106.06075
Abstract: Tobacco etch virus protease (TEVp) is a useful tool for removing fusion tag, but wild type TEVp is less stable under the oxidized redox state. In this work, we introduced and combined C19S, C110S and… read more here.
Keywords: oxidative stability; protease; de3; tevp ... See more keywords