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Published in 2020 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e20-05-0310
Abstract: Spindle checkpoint strength is dictated by the number of unattached kinetochores, cell volume and cell fate. We show that the conserved AAA-ATPase, PCH-2/TRIP13, which remodels the checkpoint effector Mad2 from an active conformation to an…
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Keywords:
media see;
spindle checkpoint;
see text;
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Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e21-08-0419
Abstract: Ovarian cancer is routinely diagnosed long after the disease has metastasized through the fibrous sub-mesothelium. Despite extensive research in the field linking ovarian cancer progression to increasingly poor prognosis, there are currently no validated cellular…
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Keywords:
ovarian cancer;
metastatic potential;
media see;
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Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-09-0391
Abstract: Recent research has elucidated mechanochemical pathways of single cell polarization, but much less is known about collective motility initiation in adhesive cell groups. We used galvanotactic assays of zebrafish keratocyte cell groups, pharmacological perturbations, electric…
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Keywords:
electric field;
cell;
text media;
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Published in 2025 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e25-05-0212
Abstract: Coordinated expression of replication-dependent (RD) histones genes occurs within the Histone Locus Body (HLB) during S phase, but the molecular steps in transcription that are cell cycle regulated are unknown. We report that Drosophila RNA…
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see text;
cell cycle;
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Published in 2025 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e25-06-0306
Abstract: The parasite Cryptosporidium causes severe diarrheal disease that can be life-threatening, and effective treatments are sorely lacking. Recently, aspartyl proteases (ASP) have emerged as targets with significant therapeutic potential in several related parasites resulting in…
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Keywords:
merozoites male;
see text;
host;
male gametes ... See more keywords