TFAM deficiency in dendritic cells leads to mitochondrial dysfunction and enhanced antitumor immunity through cGAS-STING pathway
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DOI: 10.1136/jitc-2022-005430
Abstract: Background Mitochondrial transcription factor A (TFAM) is a transcription factor that maintains mitochondrial DNA (mtDNA) stabilization and initiates mtDNA replication. However, little is known about the immune regulation function and TFAM expression in immune cells… read more here.
Keywords: sting pathway; dcs; tfam; dendritic cells ... See more keywords