Long noncoding RNA TFAP2A‐AS1 promotes oral squamous cell carcinoma cell growth and movement via competitively binding miR‐1297 and regulating TFAP2A expression
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23438
Abstract: Oral squamous cell carcinoma (OSCC) is an aggressive and common malignancy in the head and neck, characterized by poor prognosis and high incidence. This study aimed to investigate the role of long noncoding RNA TFAP2A‐AS1… read more here.
Keywords: mir 1297; cell; tfap2a as1; tfap2a ... See more keywords
TFAP2A drives non-small cell lung cancer (NSCLC) progression and resistance to targeted therapy by facilitating the ESR2-mediated MAPK pathway
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-02251-5
Abstract: Cancer is among the leading causes of death related diseases worldwide, and lung cancer has the highest mortality rate in the world. Transcription factors (TFs) constitute a class of structurally and functionally intricate proteins. Aberrant… read more here.
Keywords: lung cancer; cancer; tfap2a; nsclc progression ... See more keywords
Pancreatic Cancer-Derived Exosomes Promote the Proliferation, Invasion, and Metastasis of Pancreatic Cancer by the miR-3960/TFAP2A Axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/3590326
Abstract: Background The microRNAs (miRNAs) in cancer-derived exosomes have the ability to change tumor microenvironment. This study aims to investigate the role of miRNA in cancer-derived exosomes in pancreatic cancer (PC). Methods Based on the analysis… read more here.
Keywords: pancreatic cancer; tfap2a; mir 3960; derived exosomes ... See more keywords
Abstract 5647: Investigating the role of AP-2α in melanomagenesis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5647
Abstract: Introduction: Transcription factor AP-2α (encoded by the TFAP2A gene) is a protein involved in the early development of multiple tissues, particularly the neural crest. Melanocytes are derived from the neural crest and their development appears… read more here.
Keywords: role; melanoma; melanomagenesis; role melanomagenesis ... See more keywords
TFAP2A Upregulates SKA3 to Promote Glycolysis and Reduce the Sensitivity of Lung Adenocarcinoma Cells to Cisplatin
Sign Up to like & getrecommendations! Published in 2024 at "Pharmacology"
DOI: 10.1159/000536557
Abstract: Abstract Introduction: Studies have shown that glycolysis metabolism affects the resistance or sensitivity of tumors to chemotherapy drugs. Emerging from recent research, a paradigm-shifting revelation has unfolded, elucidating the oncogenic nature of SKA3 within the… read more here.
Keywords: luad; sensitivity; expression; ska3 ... See more keywords
DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Epigenetics"
DOI: 10.1186/s13148-017-0401-z
Abstract: BackgroundGenome-wide association studies (GWASs) have identified dozens of loci associated with gout, but for most cases, the risk genes and the underlying molecular mechanisms contributing to these associations are unknown. This study sought to understand… read more here.
Keywords: risk gene; tfap2a; transcription factor; gout risk ... See more keywords
Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214376
Abstract: Transcription factor AP-2-alpha (Tfap2a) is an important sequence-specific DNA-binding protein that can regulate the transcription of multiple genes by collaborating with inducible viral and cellular enhancer elements. In this experiment, the expression, localization, and functions… read more here.
Keywords: overexpression tfap2a; tfap2a; mouse; tfap2a mouse ... See more keywords
Immunomodulatory Effects of SPHK1 and Its Interaction with TFAP2A in Yellow Drum (Nibea albiflora)
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms252413641
Abstract: Sphingosine kinases (SPHKs) are essential enzymes that catalyze the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P), which plays pivotal roles in inflammation and immune regulation. In this study, genome-wide association analysis (GWAS) identified the Ydsphk1… read more here.
Keywords: drum; drum nibea; nibea albiflora; yellow drum ... See more keywords
Long noncoding RNA TFAP2A AS1 exerts promotive effects in non small cell lung cancer progression via controlling the microRNA 548a 3p/CDK4 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Oncology research"
DOI: 10.3727/096504022x16540075150990
Abstract: In this study, we mainly focus on probing expression profile and detailed functions of long non coding RNA TFAP2A antisense RNA 1 (TFAP2A AS1) in non small cell lung cancer (NSCLC). Moreover, the mechanisms played… read more here.
Keywords: tfap2a; cdk4; tfap2a as1; rna tfap2a ... See more keywords
Silencing of lncRNA TFAP2A-AS1 attenuates the development of acute coronary syndrome by inhibiting TFAP2A expression
Sign Up to like & getrecommendations! Published in 2025 at "Biomedical Reports"
DOI: 10.3892/br.2025.2093
Abstract: Acute coronary syndrome (ACS), the acute manifestation of ischemic heart disease, remains a major cause of morbidity and mortality worldwide. The present study aimed to elucidate the preliminarily biological role and underlying mechanism of the… read more here.
Keywords: tfap2a as1; tfap2a expression; tfap2a; as1 tfap2a ... See more keywords
TFAP2A promotes cervical cancer via a positive feedback pathway with PD‑L1
Sign Up to like & getrecommendations! Published in 2023 at "Oncology Reports"
DOI: 10.3892/or.2023.8551
Abstract: Transcription factor AP-2 alpha (TFAP2A) is a critical cell growth regulator that is overexpressed in various tumor tissues. However, its role in the development of cervical cancer remains unknown. In the present study, public databases… read more here.
Keywords: cervical cancer; tfap2a; positive feedback; tumor ... See more keywords