Tfcp2l1 safeguards the maintenance of human embryonic stem cell self‐renewal
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DOI: 10.1002/jcp.26483
Abstract: Tfcp2l1 is a transcription factor critical for mouse embryonic stem cell (mESC) maintenance. However, its role in human ESCs (hESCs) remains unclear. Here, we investigated the role of Tfcp2l1 in controlling hESC activity and showed… read more here.
Keywords: maintenance; stem cell; self renewal; embryonic stem ... See more keywords
Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro
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DOI: 10.1242/bio.059650
Abstract: We previously demonstrated gradual loss of epiblast during diapause in embryos lacking components of the LIF/IL6 receptor. Here we explore requirement for the downstream signalling transducer and activator of transcription, STAT3 and its target, TFCP2L1,… read more here.
Keywords: tfcp2l1; stem cells; stat3 target; stat3 ... See more keywords
Phosphorylation of TFCP2L1 by CDK1 is required for stem cell pluripotency and bladder carcinogenesis
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DOI: 10.15252/emmm.201910880
Abstract: Molecular programs involved in embryogenesis are frequently upregulated in oncogenic dedifferentiation and metastasis. However, their precise roles and regulatory mechanisms remain elusive. Here, we showed that CDK1 phosphorylation of TFCP2L1, a pluripotency‐associated transcription factor, orchestrated… read more here.
Keywords: cdk1; cell; pluripotency; stem ... See more keywords
Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts
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DOI: 10.7554/elife.24265
Abstract: Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. In adult kidneys, these… read more here.
Keywords: factor tfcp2l1; cell; transcription factor; tfcp2l1 ... See more keywords