Gene fusion analysis in renal cell carcinoma by FusionPlex RNA‐sequencing and correlations of molecular findings with clinicopathological features
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DOI: 10.1002/gcc.22798
Abstract: Translocation renal cell carcinoma (tRCC) affects younger patients and often presents as advanced disease. Accurate diagnosis is required to guide clinical management. Here we evaluate the RNA‐sequencing FusionPlex platform with a 115‐gene panel including TFE3… read more here.
Keywords: tfe3; analysis; rna sequencing; fusion ... See more keywords
A novel RBMX‐TFE3 gene fusion in a highly aggressive pediatric renal perivascular epithelioid cell tumor
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DOI: 10.1002/gcc.22801
Abstract: We report an Xp11 translocation perivascular epithelioid cell tumor (PEComa) with a novel RBMX‐TFE3 gene fusion, resulting from a paracentric X chromosome inversion, inv(X)(p11;q26). The neoplasm occurred in an otherwise healthy 12‐year‐old boy who presented… read more here.
Keywords: rbmx tfe3; gene fusion; rbmx; tfe3 gene ... See more keywords
RBM10‐TFE3 fusions: A FISH‐concealed anomaly in adult renal cell carcinomas displaying a variety of morphological and genomic features: Comprehensive study of six novel cases
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DOI: 10.1002/gcc.22985
Abstract: The accurate diagnosis of Xp11‐translocation renal cell carcinoma (RCC) in adults is challenging. TFE3 (located on chromosome X) fuses with a partner gene generally located on another chromosome. In rare cases TFE3 may fuse with… read more here.
Keywords: renal cell; study six; rbm10 tfe3; six novel ... See more keywords
A novel VCP::TFE3 gene fusion resulting from t(X;9)(p11.23;p13.3) chromosome translocation in TFE3 rearranged renal cancer cell carcinoma
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DOI: 10.1002/gcc.23127
Abstract: Renal cell carcinoma (RCC) with rearrangement of transcription factor for immunoglobulin heavy‐chain enhancer 3 (TFE3; TFE3‐rearranged RCC) at Xp11.2 is a rare tumor entity but the most frequent among the microphthalmia transcription factor family translocation… read more here.
Keywords: cell carcinoma; translocation; vcp tfe3; tfe3 rearranged ... See more keywords
Ocular PEComas are frequently melanotic and TFE3-translocated: report of two cases including the first description of PRCC-TFE3 fusion in PEComa
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DOI: 10.1007/s00428-020-02890-w
Abstract: Ocular perivascular epithelioid cell tumor (PEComa) is exceedingly rare. We reported two examples involving the choroid and subconjunctival tissue, respectively, in patients aged 17 and 20 years. Both tumors comprised packets and sheets of large polygonal… read more here.
Keywords: pecoma; first description; prcc tfe3; description prcc ... See more keywords
Structural basis for the dimerization mechanism of human transcription factor E3.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.06.091
Abstract: The transcription factor for immunoglobulin heavy-chain enhancer 3 (TFE3) is a member of the microphthalmia (MiT/TFE) transcription factor family. Dysregulation of TFE3 due to chromosomal abnormalities is associated with a subset of human renal cell… read more here.
Keywords: transcription factor; transcription; tfe3; dimerization mechanism ... See more keywords
Computational analysis of pathological images enables a better diagnosis of TFE3 Xp11.2 translocation renal cell carcinoma
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DOI: 10.1038/s41467-020-15671-5
Abstract: TFE3 Xp11.2 translocation renal cell carcinoma (TFE3-RCC) generally progresses more aggressively compared with other RCC subtypes, but it is challenging to diagnose TFE3-RCC by traditional visual inspection of pathological images. In this study, we collect… read more here.
Keywords: renal cell; tfe3; tfe3 rcc; translocation renal ... See more keywords
Significance of immunohistochemistry and FISH of TFE3 in the diagnosis of alveolar soft part sarcoma: A case report
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DOI: 10.1097/md.0000000000029861
Abstract: Rationale: Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma harboring an ASPL-TFE3 fusion gene. Herein, we report a case of ASPS associated with brain metastasis. Immunohistochemistry (IHC) for TFE3 antigen expression and… read more here.
Keywords: sarcoma; alveolar soft; diagnosis; case ... See more keywords
YAP1-TFE3 Gene Fusion Variant in Clear Cell Stromal Tumor of Lung: Report of Two Cases in Support of a Distinct Entity.
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DOI: 10.1111/his.14437
Abstract: AIMS Clear cell (hemangioblastoma-like) stromal tumor of the lung is a newly described, rare pulmonary neoplasm. Recurrent YAP1-TFE3 gene fusions have recently been reported in three cases. We describe two additional cases and confirm the… read more here.
Keywords: tumor lung; tfe3 gene; yap1 tfe3; fusion ... See more keywords
Diagnostic approach in TFE3-rearranged renal cell carcinoma: a multi-institutional international survey
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2020-207372
Abstract: Transcription factor E3-rearranged renal cell carcinoma (TFE3-RCC) has heterogenous morphologic and immunohistochemical (IHC) features. 131 pathologists with genitourinary expertise were invited in an online survey containing 23 questions assessing their experience on TFE3-RCC diagnostic work-up.… read more here.
Keywords: renal cell; tfe3 rcc; cell carcinoma; survey ... See more keywords
Abstract 3527: Clarification of the molecular mechanism for cancer development in Xp11.2 translocation renal cell carcinoma
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DOI: 10.1158/1538-7445.am2017-3527
Abstract: Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) is a newly defined subset of RCC, which have chromosomal translocations involving the TFE3 transcription factor at Xp11.2. All translocations seen in Xp11.2 tRCC, including PRCC-TFE3, PSF-TFE3, ASPL-TFE3,… read more here.
Keywords: cancer; tfe3; cell; xp11 translocation ... See more keywords