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   Articles with "tfeb" as a keyword



The dual and emerging role of physical exercise‐induced TFEB activation in the protection against Alzheimer's disease

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recommendations! Published in 2023 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.31005

Abstract: The mechanisms of autophagy have been related to Alzheimer's disease (AD) pathogenesis by the endosomal‐lysosomal system, having a critical function in forming amyloid‐β (Aβ) plaques. Nevertheless, the exact mechanisms mediating disease pathogenesis remain unclear. The… read more here.

Keywords: tfeb; function; disease; alzheimer disease ... See more keywords

Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy.

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recommendations! Published in 2018 at "Small"

DOI: 10.1002/smll.201703711

Abstract: Transcription factor EB (TFEB) is a master regulator of autophagy and lysosomal biogenesis. Here, silver nanoparticles (Ag NPs)-induced cytoprotective autophagy required TFEB is shown. Ag NPs-induced nucleus translocation of TFEB through a well-established mechanism involving… read more here.

Keywords: nucleus translocation; cytoprotective autophagy; induced cytoprotective; autophagy ... See more keywords

Silica Nanoparticles Trigger Chaperone HSPB8-Assisted Selective Autophagy via TFEB Activation in Hepatocytes.

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recommendations! Published in 2022 at "Small"

DOI: 10.1002/smll.202204310

Abstract: Silica nanoparticles (SiNPs) are one of the most common inorganic nanomaterials. Autophagy is the predominant biological response to nanoparticles and transcription factor EB (TFEB) is a master regulator of the autophagy-lysosome pathway. Previous studies show… read more here.

Keywords: tfeb; assisted selective; silica nanoparticles; hspb8 ... See more keywords

Ca2+-Dependent Regulation of TFEB and Lysosomal Function.

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recommendations! Published in 2019 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-9018-4_13

Abstract: Lysosomes are emerging as calcium store organelles that can modulate various intracellular processes such as the regulation of nutrient signaling through the activation of TFEB, a master gene for lysosomal function, or very specialized functions… read more here.

Keywords: tfeb; ca2 dependent; tfeb lysosomal; lysosomal function ... See more keywords

Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis

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recommendations! Published in 2018 at "Cell"

DOI: 10.1016/j.cell.2018.10.044

Abstract: Nervous system function depends on proper myelination for insulation and critical trophic support for axons. Myelination is tightly regulated spatially and temporally, but how it is controlled molecularly remains largely unknown. Here, we identified key… read more here.

Keywords: cns myelination; myelination; programmed cell; cell death ... See more keywords

Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity.

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recommendations! Published in 2020 at "Developmental cell"

DOI: 10.1016/j.devcel.2020.10.010

Abstract: Liquid-liquid phase separation (LLPS) compartmentalizes transcriptional condensates for gene expression, but little is known about how this process is controlled. Here, we showed that depletion of IPMK, encoding inositol polyphosphate multikinase, promotes autophagy and lysosomal… read more here.

Keywords: phase separation; liquid phase; inositol polyphosphate; liquid liquid ... See more keywords

Ginsenoside-Rh2 Promotes Functional Recovery after Spinal Cord Injury by Enhancing TFEB-Mediated Autophagy.

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recommendations! Published in 2024 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.4c02379

Abstract: Background: Following spinal cord injury (SCI), autophagy plays a positive role in neuronal protection, whereas pyroptosis triggers an inflammatory response. Ginsenoside-Rh2 (GRh2), known for its neuroprotective effects, is considered a promising drug. However, the exact… read more here.

Keywords: functional recovery; spinal cord; tfeb; grh2 ... See more keywords

Enhanced SIRT1-TFEB Interaction Promotes Lysosome Biogenesis and Autophagy by Reducing TFEB Acetylation: Revealing the Enterotoxicity Disparity of Deoxynivalenol and T-2 Toxin.

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recommendations! Published in 2025 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.5c01854

Abstract: Multiple environmental factors contribute to digestive system damage caused by food contamination in both humans and animals. Mycotoxins, such as deoxynivalenol (DON) and T-2 toxin, have emerged as the most significant factors due to their… read more here.

Keywords: deoxynivalenol toxin; tfeb; tfeb acetylation; acetylation ... See more keywords

TFEB rearranged renal cell carcinoma. A clinicopathologic and molecular study of 13 cases. Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1

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recommendations! Published in 2020 at "Modern Pathology"

DOI: 10.1038/s41379-020-00713-6

Abstract: Renal cell carcinomas with t(6;11) chromosome translocation has been classically characterized by the rearrangement of the TFEB gene, located on chromosome 6, and MALAT1 gene, located on chromosome 11. Recently, a few other genes have… read more here.

Keywords: renal cell; cell carcinoma; tfeb rearranged; rearranged renal ... See more keywords

AKT modulates the autophagy-lysosome pathway via TFEB

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recommendations! Published in 2017 at "Cell Cycle"

DOI: 10.1080/15384101.2017.1337968

Abstract: The serine and threonine kinase AKT (also known as protein kinase B, PKB) integrates inputs from growth factors and metabolic effectors to control key multifunctional signaling hubs via direct phosphorylation of substrates that control cell… read more here.

Keywords: akt; activity; lysosome pathway; autophagy lysosome ... See more keywords

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

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recommendations! Published in 2019 at "Autophagy"

DOI: 10.1080/15548627.2019.1586246

Abstract: ABSTRACT N6-methyladenosine (m6A) mRNA modifications play critical roles in various biological processes. However, no study addresses the role of m6A in macroautophagy/autophagy. Here, we show that m6A modifications are increased in H/R-treated cardiomyocytes and ischemia/reperfusion… read more here.

Keywords: protein; treated cardiomyocytes; mettl3 alkbh5; autophagy ... See more keywords