Transcription factor EB (TFEB)-mediated autophagy protects against ethyl carbamate-induced cytotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2018.10.037
Abstract: Ethyl carbamate (EC) is thought to be a toxicant that widely exists in cigarette smoke and polluted air, as well as fermented food and alcoholic beverages. However, the mechanism and approach to treat hepatic damage… read more here.
Keywords: mediated autophagy; factor tfeb; transcription factor; tfeb mediated ... See more keywords
RGS10 Negatively Regulates Apical Periodontitis via TFEB-mediated Autophagy in BABL/c Mice Model and in vitro.
Sign Up to like & getrecommendations! Published in 2023 at "International endodontic journal"
DOI: 10.1111/iej.13924
Abstract: AIM Apical periodontitis is a prevalent oral inflammatory disease that has recently been linked to transcription factor EB (TFEB)-mediated autophagy. Regulator of G-protein signaling 10 (RGS10) is reported to be an effective regulator of the… read more here.
Keywords: mediated autophagy; apical periodontitis; rgs10; tfeb mediated ... See more keywords
Cyclosporine A blocks autophagic flux in tubular epithelial cells by impairing TFEB‐mediated lysosomal function
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16593
Abstract: Cyclosporine A (CsA) is an immunosuppressor widely used for the prevention of acute rejection during solid organ transplantation. However, severe nephrotoxicity has substantially limited its long‐term usage. Recently, an impaired autophagy pathway was suggested to… read more here.
Keywords: epithelial cells; tfeb mediated; tubular epithelial; cyclosporine ... See more keywords
TFEB-mediated lysosomal exocytosis alleviates high-fat diet–induced lipotoxicity in the kidney
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.162498
Abstract: Obesity is a major risk factor for end-stage kidney disease. We previously found that lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in obesity-related kidney disease, in both humans and experimental animal models. However,… read more here.
Keywords: tfeb; lysosomal exocytosis; mediated lysosomal; kidney ... See more keywords