Celastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2046437
Abstract: ABSTRACT Alzheimer disease (AD) is the most common neurodegenerative disease. Unfortunately, current effective therapeutics for AD are limited and thus the discovery of novel anti-AD agents is urgently needed. A key pathological hallmark of AD… read more here.
Keywords: tau; mapt tau; alzheimer disease; transcription factor ... See more keywords
EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002034
Abstract: The stress-responsive transcription factor EB (TFEB) is a master controller of lysosomal biogenesis and autophagy and plays a major role in several cancer-associated diseases. TFEB is regulated at the posttranslational level by the nutrient-sensitive kinase… read more here.
Keywords: tfeb; tfeb transcription; egr1; response starvation ... See more keywords