A functional polymorphism in TFF1 promoter is associated with the risk and prognosis of gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31197
Abstract: Trefoil Factor 1 (TFF1, also named pS2), which serves as the gastrointestinal mucosal protector, is known as gastric‐specific tumor suppressor gene. However, the genetic variants of TFF1 are still not well studied. In our study,… read more here.
Keywords: risk; prognosis gastric; gastric cancer; prognosis ... See more keywords
Loss of trefoil factor 1 inhibits biliary regeneration but accelerates the hepatic differentiation of progenitor cells in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.023
Abstract: Although the regeneration of the adult liver depends on hepatic progenitor cells (HPCs), many uncertainties regarding hepatic regeneration in the injured liver remain. Trefoil factor family 1 (TFF1), a secretory protein predominantly expressed in the… read more here.
Keywords: progenitor cells; regeneration; liver; tff1 ... See more keywords
Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett’s epithelium
Sign Up to like & getrecommendations! Published in 2022 at "Laboratory Investigation"
DOI: 10.1038/s41374-022-00771-1
Abstract: Trefoil factor family 1 (TFF1) is one of three members of the trefoil factor family that are abundantly expressed in the gastrointestinal mucosal epithelium. Recent studies have shown that TFF1 acts as a tumor suppressor… read more here.
Keywords: barrett epithelium; development; epithelium; eac ... See more keywords
Gastric TFF1 Expression from Acute to Chronic Helicobacter Infection
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2017.00434
Abstract: TFF1, a mucin-associated secreted peptide of gastric mucous cells, is known as a protective agent for stomach epithelium under different stimuli, but its role upon Helicobacter infection is still not clear. In this paper we… read more here.
Keywords: tff1; helicobacter infection; infection; expression acute ... See more keywords
Downregulation of the Tumor Suppressor TFF1 Is Required during Induction of Colon Cancer Progression by L1
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14184478
Abstract: Simple Summary Aberrant activation of Wnt/β-catenin signaling and the subsequent induction of downstream target genes is a hallmark of colorectal cancer (CRC) development. Previously, we found that overexpression of the immunoglobulin-like cell adhesion receptor L1CAM… read more here.
Keywords: tumor suppressor; tff1; crc; tumor ... See more keywords