Histomorphometric Parameters of the Growth Plate and Trabecular Bone in Wild-Type and Trefoil Factor Family 3 (Tff3)-Deficient Mice Analyzed by Free and Open-Source Image Processing Software
Sign Up to like & getrecommendations! Published in 2017 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927617000630
Abstract: Abstract Trefoil factor family 3 (Tff3) peptide is present during intrauterine endochondral ossification in mice, and its deficiency affects cancellous bone quality in secondary ossification centers of mouse tibiae. The aim of this study was… read more here.
Keywords: bone; mice; trabecular bone; open source ... See more keywords
Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c00767
Abstract: TFF3 regulates essential gastro- and neuroprotective functions, but its molecular mode of action remains poorly understood. Synthetic intractability and lack of reliable bioassays and validated receptors are bottlenecks for mechanistic and structure–activity relationship studies. Here,… read more here.
Keywords: synthesis tff3; stable metabolite; gut stable; chemical synthesis ... See more keywords
TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12315-1
Abstract: Intestinal epithelial cells (IEC) have important functions in nutrient absorption, barrier integrity, regeneration, pathogen-sensing, and mucus secretion. Goblet cells are a specialized cell type of IEC that secrete Trefoil factor 3 (TFF3) to regulate mucus… read more here.
Keywords: wound healing; tff3 interacts; colitis; egfr activation ... See more keywords
Localization of trefoil factor family peptide 3 (TFF3) in epithelial tissues originating from the three germ layers of developing mouse embryo.
Sign Up to like & getrecommendations! Published in 2017 at "Bosnian journal of basic medical sciences"
DOI: 10.17305/bjbms.2017.1838
Abstract: Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Mature epithelial tissues originate from different embryonic germ layers. The objective of this research was to explore the presence… read more here.
Keywords: localization; germ layers; tff3 peptide; mouse ... See more keywords
Mouse trefoil factor 3 (Tff3) ameliorates fatty liver phenotype via increasing peroxisome proliferator-activated receptor-α (PPARα) expression
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.23780
Abstract: // Xiaojie Wu 1, * , Haiyong Jin 2, * , Yueling Zhang 3 , Mingyuan Dong 3 , Xiaoting Wu 3 , Jiadi Zhou 1 , Weishan Zhuge 4 , Jianjing Yang 5 ,… read more here.
Keywords: medical university; china department; fatty liver; tff3 ... See more keywords
Cost-Benefit Analysis of the Introduction of Mp-Mri Guided Biopsies in Croatia.
Sign Up to like & getrecommendations! Published in 2018 at "Acta clinica Croatica"
DOI: 10.20471/acc.2018.57.s1.06
Abstract: The objective of this study was to determine differential expression of TFF1, TFF2 and TFF3 genes and proteins in breast tumor subtypes. In addition, we investigated the correlation between TFF genes within tumor subgroups, and… read more here.
Keywords: expression; tff1 tff3; tff3 genes; tff3 ... See more keywords
Different Molecular Forms of TFF3 in the Human Respiratory Tract: Heterodimerization with IgG Fc Binding Protein (FCGBP) and Proteolytic Cleavage in Bronchial Secretions
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315359
Abstract: The polypeptide TFF3 belongs to the trefoil factor family (TFF) of lectins. TFF3 is typically secreted from mucous epithelia together with mucins. Both intestinal and salivary TFF3 mainly exist as disulfide-linked heterodimers with IgG Fc… read more here.
Keywords: binding protein; tff3; different molecular; igg binding ... See more keywords
Tff3 Deficiency Protects against Hepatic Fat Accumulation after Prolonged High-Fat Diet
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12081288
Abstract: Trefoil factor 3 (Tff3) protein is a small secretory protein expressed on various mucosal surfaces and is involved in proper mucosal function and recovery via various mechanisms, including immune response. However, Tff3 is also found… read more here.
Keywords: tff3; accumulation; tff3 deficiency; high fat ... See more keywords
Modulation of the Intestinal Barrier Integrity and Repair by Microbiota Extracellular Vesicles through the Differential Regulation of Trefoil Factor 3 in LS174T Goblet Cells
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15112437
Abstract: Trefoil factor 3 (TFF3) plays a key role in the maintenance and repair of intestinal mucosa. TFF3 expression is upregulated by the microbiota through TLR2. At the posttranscriptional level, TFF3 is downregulated by miR-7-5p. Reduced… read more here.
Keywords: extracellular vesicles; trefoil factor; microbiota extracellular; tff3 ... See more keywords