Identification of Antigen Presenting Cell Subsets Supporting Human Tfh Differentiation.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1736-6_11
Abstract: CD4+ T follicular helper (Tfh) cells are essential for initiating and regulating efficient humoral responses in secondary lymphoid organs. Tfh polarization and differentiation is driven by multiple stimuli delivered by antigen presenting cells (APCs). APCs… read more here.
Keywords: human tfh; identification antigen; tfh; biology ... See more keywords
GALT CD4+PD-1hi T follicular helper (Tfh) cells repopulate after anti-retroviral therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2021.104396
Abstract: Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections are characterized by dramatic alterations in the mucosal CD4 T cell compartment. Though viremia is effectively suppressed, and peripheral CD4 T cell numbers recover to… read more here.
Keywords: anti retroviral; tfh; tfh cells; retroviral therapy ... See more keywords
CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2019.12.016
Abstract: T follicular helper (Tfh) cells are fundamental for B cell selection and antibody maturation in germinal centers. Circulating Tfh (cTfh) cells constitute a minor proportion of the CD4+ T cells in peripheral blood, but their… read more here.
Keywords: cd4 cells; tfh; blood; non tfh ... See more keywords
The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.07.004
Abstract: Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE… read more here.
Keywords: tfr cells; tfh; follicular regulatory; ratio ... See more keywords
Tfh cells set the stage for tumor control.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.11.013
Abstract: The microbiome has a profound influence on the development and progression of cancer, as well as the response to immunotherapy. In this issue of Immunity, Overacre-Delgoffe et al. (2021) examine the impact of the immunogenic bacteria… read more here.
Keywords: tumor; tfh cells; cells set; tfh ... See more keywords
Administration of a microRNA-21 inhibitor improves the lupus-like phenotype in MRL/lpr mice by repressing Tfh cell-mediated autoimmune responses.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108578
Abstract: BACKGROUND Inhibiting Tfh cell overexpansion prevents autoimmune responses and disease flares in systemic lupus erythematosus (SLE). miR-21 is highly expressed in SLE CD4+ T cells, but whether inhibiting miR-21 can reduce Tfh cell expansion and… read more here.
Keywords: tfh cell; lpr mice; mrl lpr; tfh ... See more keywords
Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-020-00554-y
Abstract: During viral infection, immune cells coordinate the induction of inflammatory responses that clear infection and humoral responses that promote protection. CD4+ T-cell differentiation sits at the center of this axis. Differentiation toward T-helper 1 (Th1)… read more here.
Keywords: transcription; cell; tfh; helper ... See more keywords
Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06686-0
Abstract: Follicular helper T (TFH) cells are expanded in systemic lupus erythematosus, where they are required to produce high affinity autoantibodies. Eliminating TFH cells would, however compromise the production of protective antibodies against viral and bacterial… read more here.
Keywords: tfh; glucose metabolism; follicular helper; tfh cells ... See more keywords
Notch2-dependent DC2s mediate splenic germinal center responses
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1809925115
Abstract: Significance High-affinity antibody responses involve selection of B cells in the germinal center (GC) by cognate interactions with T follicular helper (TFH) cells, which in turn must first be activated by classical dendritic cells (cDCs).… read more here.
Keywords: germinal center; notch2 dependent; tfh; cell ... See more keywords
Strong influenza-induced TFH generation requires CD4 effectors to recognize antigen locally and receive signals from continuing infection
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111064119
Abstract: Significance Influenza infection elicits strong, long-lived protective antibodies, but most current influenza vaccines give weaker, short-lived protection. We noted that live virus is still replicating, making antigen and causing inflammation at 7 d postinfection (dpi),… read more here.
Keywords: infection; antigen; effector phase; tfh ... See more keywords
Role of Tfh17 cells in patients with multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2106400
Abstract: ABSTRACT Objective Follicular helper T cells (Tfh) drive proliferation and differentiation of B cells into plasma cells, leading to antibody production; however, their role in multiple myeloma (MM) is unknown. We aimed to determine the… read more here.
Keywords: role; tfh17 cells; tfh17 tfh; multiple myeloma ... See more keywords