Human pregnancy levels of estrogen and progesterone contribute to humoral immunity by activating TFH/B cell axis
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048658
Abstract: Circulating TFH (cTFH) cells express CXCR5, PD‐1, and, when activated, ICOS, and release IL‐21. According to the production of IFN‐γ, IL‐4, and IL‐17 and expression of FoxP3, these cells are also classified as cTFH1, cTFH2,… read more here.
Keywords: pregnancy; ctfh; tfh cell; humoral immunity ... See more keywords
Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation.
Sign Up to like & getrecommendations! Published in 2021 at "Immunobiology"
DOI: 10.1016/j.imbio.2021.152147
Abstract: Autoimmune regulator (Aire) is a transcription factor that plays a pivotal role in the maintenance of immune tolerance. However, little is known about its roles in peripheral immune tolerance. Aire is predominantly expressed in dendritic… read more here.
Keywords: dc2 cells; cell differentiation; aire; tfh cell ... See more keywords
"Are you gonna go my way?"-Decisions at the Tfh-B cell interface.
Sign Up to like & getrecommendations! Published in 2022 at "Immunity"
DOI: 10.1016/j.immuni.2022.02.002
Abstract: The generation of memory B cells and plasma cells is complex and involves inputs from the microenvironment, notably from T follicular helper cells. In last month's issue of Immunity, Yeh et al. and Song et al. refine… read more here.
Keywords: decisions tfh; way decisions; tfh cell; cell interface ... See more keywords
Administration of a microRNA-21 inhibitor improves the lupus-like phenotype in MRL/lpr mice by repressing Tfh cell-mediated autoimmune responses.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108578
Abstract: BACKGROUND Inhibiting Tfh cell overexpansion prevents autoimmune responses and disease flares in systemic lupus erythematosus (SLE). miR-21 is highly expressed in SLE CD4+ T cells, but whether inhibiting miR-21 can reduce Tfh cell expansion and… read more here.
Keywords: tfh cell; lpr mice; mrl lpr; tfh ... See more keywords
IL-2 contributes to cirrhosis-associated immune dysfunction by impairing follicular T helper cells in advanced cirrhosis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2020.10.012
Abstract: BACKGROUND AND AIMS Patients with decompensated liver cirrhosis suffer from recurrent infections and inadequate responses to prophylactic vaccinations. However, many patients present with hypergammaglobulinemia (HGG), indicating a sustained ability to generate antibody responses. As follicular… read more here.
Keywords: tfh cell; cirrhosis; tfh cells; follicular helper ... See more keywords
Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15855-z
Abstract: Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol… read more here.
Keywords: arthritis; autoimmune; development autoimmune; tfh cell ... See more keywords
Influenza vaccination stimulates maturation of the human T follicular helper cell response
Sign Up to like & getrecommendations! Published in 2024 at "Nature Immunology"
DOI: 10.1038/s41590-024-01926-6
Abstract: The differentiation and specificity of human CD4+ T follicular helper cells (TFH cells) after influenza vaccination have been poorly defined. Here we profiled blood and draining lymph node (LN) samples from human volunteers for over… read more here.
Keywords: tfh cell; influenza; tfh cells; vaccination ... See more keywords
Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213793120
Abstract: Significance Tfh cells are indispensable for effective humoral immunity against infection but detrimental in autoimmune diseases. We demonstrate that LXR, an oxysterol sensor previously known to integrate metabolic and inflammatory signaling, acts as a critical… read more here.
Keywords: tfh cell; cell differentiation; cell; liver receptor ... See more keywords
The hippo kinase MST1 negatively regulates the differentiation of follicular helper T cells
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13590
Abstract: Follicular helper T (TFH) cells are essential for inducing germinal centre (GC) reactions to mediate humoral adaptive immunity and antiviral effects, but the mechanisms of TFH cell differentiation remain unclear. Here, we found that the… read more here.
Keywords: tfh cell; hippo kinase; differentiation; cell differentiation ... See more keywords
Methotrexate Exhibits a Dual Role in Regulation of CD4+ T Follicular Helper (Tfh) Cell Differentiation and Activity.
Sign Up to like & getrecommendations! Published in 2025 at "Scandinavian journal of immunology"
DOI: 10.1111/sji.70071
Abstract: Methotrexate (MTX) is one of the most prevalent drugs used in the treatment of autoimmune disorders as it has an established role in preventing T and B cell proliferation which reduces the severity of autoimmunity.… read more here.
Keywords: cell differentiation; tfh cell; role; cell ... See more keywords
Translational regulation of TFH cell differentiation and autoimmune pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo1782
Abstract: Little is known regarding T cell translational regulation. We demonstrate that T follicular helper (TFH) cells use a previously unknown mechanism of selective messenger RNA (mRNA) translation for their differentiation, role in B cell maturation,… read more here.
Keywords: tfh cell; cell; autoimmune pathogenesis; regulation ... See more keywords