Interferon-α regulates abnormally increased expression of RSAD2 in Th17 and Tfh cells in systemic lupus erythematosus patients.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350420
Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that often involves abnormal activation of regulatory interferon genes and regulation of B cells by CD4+ T cells. RSAD2 is a viral suppressor protein regulated by… read more here.
Keywords: tfh cells; th17; expression; systemic lupus ... See more keywords
Oxymatrine ameliorates rheumatoid arthritis by regulation of Tfr/Tfh cells balance via TLR9-MyD88-STAT3 signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12674
Abstract: BACKGROUNG Oxymatrine (OMT) is one of the authentic Chinese herbal medicines which has rich and complex active ingredients. However, the relevant potential targets of oxymatrine on rheumatoid arthritis and the mechanism remains unreported. The aim… read more here.
Keywords: myd88 stat3; tfh cells; rheumatoid arthritis; arthritis ... See more keywords
Identification of T Peripheral Helper (Tph) Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1736-6_6
Abstract: T peripheral helper (Tph) cells represent a T cell population that stimulates B cell responses within peripheral tissues. Like T follicular helper (Tfh) cells, PD-1hi CXCR5- CD4+ Tph cells produce IL-21 and CXCL13, yet these… read more here.
Keywords: tph; peripheral helper; tph cells; tfh cells ... See more keywords
Follicular helper T cell and memory B cell immunity in CHC patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-01735-z
Abstract: Chronic hepatitis C (CHC) is associated with biological activity of T follicular helper (Tfh) cells and memory B cells (MBCs). However, the nature of Tfh cell subsets that are responsible for MBCs in CHC patients… read more here.
Keywords: chc patients; tfh cells; cd4 cxcr5; chc ... See more keywords
GALT CD4+PD-1hi T follicular helper (Tfh) cells repopulate after anti-retroviral therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2021.104396
Abstract: Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections are characterized by dramatic alterations in the mucosal CD4 T cell compartment. Though viremia is effectively suppressed, and peripheral CD4 T cell numbers recover to… read more here.
Keywords: anti retroviral; tfh; tfh cells; retroviral therapy ... See more keywords
Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.03.007
Abstract: Within lymph nodes (LNs), T follicular helper (TFH) cells help B cells to produce antibodies, which can either be protective or autoreactive. Here, we demonstrate that murine LN stromal cells (LNSCs) suppress the formation of… read more here.
Keywords: generate antigen; cell responses; stromal cells; antigen specific ... See more keywords
Altered circulating T follicular helper cell subsets in patients with psoriasis vulgaris.
Sign Up to like & getrecommendations! Published in 2017 at "Immunology letters"
DOI: 10.1016/j.imlet.2016.09.008
Abstract: Circulating T follicular helper (Tfh) cells in the blood are counterparts to conventional Tfh cells in germinal centres. Similarly to conventional Tfh cells, circulating Tfh cells provide helpful signals for B cells. Circulating Tfh cells… read more here.
Keywords: psoriasis; circulating tfh; cell subsets; tfh cells ... See more keywords
Tfh cells set the stage for tumor control.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.11.013
Abstract: The microbiome has a profound influence on the development and progression of cancer, as well as the response to immunotherapy. In this issue of Immunity, Overacre-Delgoffe et al. (2021) examine the impact of the immunogenic bacteria… read more here.
Keywords: tumor; tfh cells; cells set; tfh ... See more keywords
Exploring the imbalance of circulating follicular helper CD4+ T cells in sarcoidosis patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.02.002
Abstract: BACKGROUND Sarcoidosis is a systemic granulomatous disease characterized by the combination of Th1 and Th17 responses. Recently, several arguments have suggested a potential involvement of B cells as well as T cells in the pathogenesis… read more here.
Keywords: tfh cells; sarcoidosis; follicular helper; helper cd4 ... See more keywords
IL-2 contributes to cirrhosis-associated immune dysfunction by impairing follicular T helper cells in advanced cirrhosis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2020.10.012
Abstract: BACKGROUND AND AIMS Patients with decompensated liver cirrhosis suffer from recurrent infections and inadequate responses to prophylactic vaccinations. However, many patients present with hypergammaglobulinemia (HGG), indicating a sustained ability to generate antibody responses. As follicular… read more here.
Keywords: tfh cell; cirrhosis; tfh cells; follicular helper ... See more keywords
Acute inflammatory arthritis: Methotrexate for chronic chikungunya arthritis?
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2018.21
Abstract: T cells in blood mark Sjögren syndrome activity Blood T follicular regulatory (TFR) cells and T follicular helper (TFH) cells could serve as biomarkers of ectopic lymphoid activity in primary Sjögren syndrome (pSS). In 16… read more here.
Keywords: acute inflammatory; tfr cells; cells blood; tfh cells ... See more keywords