mTORC2 contributes to systemic autoimmunity
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DOI: 10.1111/imm.13594
Abstract: The development of many systemic autoimmune diseases, including systemic lupus erythematosus, is associated with overactivation of the type I interferon (IFN) pathway, lymphopenia and increased follicular helper T (Tfh)‐cell differentiation. However, the cellular and molecular… read more here.
Keywords: tfh differentiation; mtorc2; cell; systemic autoimmunity ... See more keywords
EZH2 Promotes T Follicular Helper Cell Differentiation Through Enhancing STAT3 Phosphorylation in Patients With Primary Sjögren’s Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.922871
Abstract: Objectives Enhancer of zeste homolog 2 (EZH2) is an epigenetic regulator that plays an essential role in immune system development and autoimmune diseases. This study aimed to characterize the role of EZH2 in the pathogenesis… read more here.
Keywords: ezh2 expression; tfh differentiation; cd4 cells; ezh2 ... See more keywords