Identification of new lead molecules against anticancer drug target TFIIH subunit P8 using biophysical and molecular docking studies.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105021
Abstract: The identification of molecules, which could modulate protein-protein interactions (PPIs), is of primary interest to medicinal chemists. Using biophysical methods during the current study, we have screened 76 compounds (grouped into 16 mixtures) against the… read more here.
Keywords: docking studies; molecular docking; drug target; using biophysical ... See more keywords
Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09270-2
Abstract: The TFIIH subunit XPB is involved in combined Xeroderma Pigmentosum and Cockayne syndrome (XP-B/CS). Our analyses reveal that XPB interacts functionally with KAT2A, a histone acetyltransferase (HAT) that belongs to the hSAGA and hATAC complexes.… read more here.
Keywords: chromatin; kat2a; tfiih; gene expression ... See more keywords
Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-&kgr;B and AP-1 signalling
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvx198
Abstract: Aims Spironolactone (SPL) improves endothelial dysfunction and survival in heart failure. Immune modulation, including poorly understood mineralocorticoid receptor (MR)-independent effects of SPL might contribute to these benefits and possibly be useful in other inflammatory cardiovascular… read more here.
Keywords: xpb; degradation; suppression; spl ... See more keywords
Pharmacological targeting of TFIIH suppresses KRAS mutant pancreatic ductal adenocarcinoma and synergizes with TRAIL.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-4222
Abstract: Pancreatic ductal adenocarcinoma (PDAC) typically presents as metastatic disease at diagnosis and remains refractory to treatment. Next generation sequencing efforts have described the genomic landscape, classified molecular subtypes, and confirmed frequent alterations in major driver… read more here.
Keywords: pancreatic ductal; kras mutant; ductal adenocarcinoma; tfiih ... See more keywords
TFIIH localization is highly dynamic during zygotic genome activation in Drosophila, and its depletion causes catastrophic mitosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.211631
Abstract: ABSTRACT In Drosophila, zygotic genome activation occurs in pre-blastoderm embryos during rapid mitotic divisions. How the transcription machinery is coordinated to achieve this goal in a very brief time span is still poorly understood. Transcription… read more here.
Keywords: drosophila; transcription; mitosis; genome activation ... See more keywords