Anti-tissue factor pathway inhibitor (TFPI) therapy: a novel approach to the treatment of haemophilia
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Hematology"
DOI: 10.1007/s12185-018-2548-6
Abstract: Novel approaches to the treatment of haemophilia are needed due to the limitations of the current standard of care, factor replacement therapy. Aspirations include lessening the treatment burden and effectively preventing joint damage. Treating haemophilia… read more here.
Keywords: inhibitor; treatment; tissue factor; factor ... See more keywords
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.070
Abstract: Endoplasmic reticulum (ER) stress has been shown to play a key role during the initiation and clinical progression of the cardiovascular diseases, such as atherosclerosis. We have recently shown that expression of tissue factor pathway… read more here.
Keywords: inhibitor; tissue factor; pathway; stress ... See more keywords
Regulation of TFPIα expression by miR-27a/b-3p in human endothelial cells under normal conditions and in response to androgens
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43500
Abstract: The increased risk of cardiovascular events in older men is multifactorial, but the significant reduction of testosterone levels has been involved. As this hormone regulates the expression of TFPI by unknown mechanisms, we aimed to… read more here.
Keywords: regulation tfpi; tfpi expression; mir 27a; tfpi ... See more keywords
Target‐mediated drug disposition modeling of an anti‐TFPI antibody (MG1113) in cynomolgus monkeys to predict human pharmacokinetics and pharmacodynamics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15244
Abstract: MG1113 is a human monoclonal antibody of tissue factor pathway inhibitor (TFPI) under development for prophylaxis for hemophilia patients with or without inhibitors against factor VIII products, which have been used for the treatment of… read more here.
Keywords: disposition modeling; antibody; mediated drug; tfpi ... See more keywords
Intrauterine lethality in Tfpi gene disrupted mice is differentially suppressed during mid‐ and late‐gestation by platelet TFPIα overexpression
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15299
Abstract: Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein required for murine embryonic development. Intrauterine lethality of Tfpi−/− mice occurs at mid‐ and late gestation, the latter of which is associated with severe cerebrovascular defects.… read more here.
Keywords: intrauterine lethality; mid late; lethality tfpi; late gestation ... See more keywords
A hydrophobic patch (PLVIVG; 1481–1486) in the B‐domain of factor V‐short is crucial for its synergistic TFPIα‐cofactor activity with protein S and for the formation of the FXa‐inhibitory complex comprising FV‐short, TFPIα, and protein S
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15690
Abstract: Factor V‐short (FV756‐1458) is a natural splice variant functioning in synergy with protein S as tissue factor pathway inhibitor alpha (TFPIα)–cofactor in inhibition of factor Xa (FXa). An exposed acid region (AR2; 1493–1537) in the… read more here.
Keywords: factor short; tfpi cofactor; tfpi; protein ... See more keywords
Major Reservoir for Heparin-Releasable TFPIα (Tissue Factor Pathway Inhibitor α) Is Extracellular Matrix
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.120.315728
Abstract: Supplemental Digital Content is available in the text. Objective: Human endothelial cells produce 2 alternatively spliced TFPI (tissue factor pathway inhibitor) isoforms that maintain anticoagulant properties of the vasculature. TFPIβ is glycosylphosphatidylinositol anchored on the… read more here.
Keywords: releasable tfpi; tissue factor; heparin releasable; tfpi ... See more keywords
Abstract 15554: Mendelian Randomization of 436 Circulating Proteins Identifies Putatively Causal Proteins for Cardiovascular Disease and Its Risk Factors
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.15554
Abstract: Introduction: Despite numerous efforts to understand the molecular mechanisms underlying cardiovascular disease, it remains the leading cause of death worldwide. Circulating proteins are frequently used as clinical biomarkers and may serve as effective drug targets.… read more here.
Keywords: mendelian randomization; causal proteins; tfpi; cardiovascular disease ... See more keywords
BFPI: A Minimal Prothrombinase Inhibitor from the Saliva of Simulium Vittatum
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DOI: 10.1182/blood-2018-99-118666
Abstract: Background: The black fly, Simulium Vittatum, has an anticoagulant protein in its saliva that allows it to feed on mammalian blood (black fly protease inhibitor; BFPI). Remarkably, BFPI is similar to the human anticoagulant tissue… read more here.
Keywords: bfpi; fxa; inhibitor; inhibition ... See more keywords
Differences in the Coagulation Profile in Women with Mild and Severe Preeclampsia
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DOI: 10.1182/blood-2020-137401
Abstract: Introduction:Different coagulations abnormalities have been referred in women with early oncet preeclampsia (EOP), but there are only few studies comparing those changes regarding to the severity of the disease. Aim:In this study we aimed to… read more here.
Keywords: coagulation; group; time; preeclampsia ... See more keywords
Tissue factor pathway inhibitor is required for cerebrovascular development in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020006054
Abstract: Tissue factor pathway inhibitor (TFPI) inhibits proteases in the blood coagulation cascade that lead to the production of thrombin, including prothrombinase (FXa/FVa), the catalytic complex that directly generates thrombin. Thus, TFPI and FV are directly… read more here.
Keywords: factor pathway; tissue factor; pathology; development ... See more keywords