The preAR2 region (1458–1492) in factor V‐Short is crucial for the synergistic TFPIα‐cofactor activity with protein S and the assembly of a trimolecular factor Xa‐inhibitory complex comprising FV‐Short, protein S, and TFPIα
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DOI: 10.1111/jth.15547
Abstract: Factor V‐Short (FV756‐1458) is a natural splice variant in which 702 residues are deleted from the B domain. It exposes an acid region (AR2; 1493–1537) that binds tissue factor pathway inhibitor alpha (TFPIα). Protein S… read more here.
Keywords: factor short; protein; tfpi cofactor; factor ... See more keywords
A hydrophobic patch (PLVIVG; 1481–1486) in the B‐domain of factor V‐short is crucial for its synergistic TFPIα‐cofactor activity with protein S and for the formation of the FXa‐inhibitory complex comprising FV‐short, TFPIα, and protein S
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15690
Abstract: Factor V‐short (FV756‐1458) is a natural splice variant functioning in synergy with protein S as tissue factor pathway inhibitor alpha (TFPIα)–cofactor in inhibition of factor Xa (FXa). An exposed acid region (AR2; 1493–1537) in the… read more here.
Keywords: factor short; tfpi cofactor; tfpi; protein ... See more keywords