Durable treatment-free remission in patients with chronic myeloid leukemia in chronic phase following frontline nilotinib: 96-week update of the ENESTfreedom study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2604-x
Abstract: PurposeENESTfreedom is evaluating treatment-free remission (TFR) following frontline nilotinib in patients with chronic myeloid leukemia (CML) in chronic phase. Following our primary analysis at 48 weeks, we here provide an updated 96-week analysis.MethodsAttempting TFR required ≥ 3 years… read more here.
Keywords: phase; week; following frontline; treatment ... See more keywords
The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.07.004
Abstract: Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE… read more here.
Keywords: tfr cells; tfh; follicular regulatory; ratio ... See more keywords
Transferrin’ across the blood–brain barrier
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-020-00102-3
Abstract: 444 | JulY 2020 | volume 19 Delivery of protein therapies to the brain has proven difficult because of the need to cross the blood–brain barrier (BBB). Now, two recent papers from researchers at Denali… read more here.
Keywords: atv bace1; etv ids; mice; brain ... See more keywords
ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells
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DOI: 10.1101/2021.09.14.460384
Abstract: ICOS signaling promotes T follicular regulatory cell differentiation during germinal center reaction safeguarding against autoantibody production. ICOS is a T-cell costimulatory receptor critical for Tfh cell generation and function. However, the role of ICOS in… read more here.
Keywords: cell; icos costimulation; follicular regulatory; differentiation ... See more keywords
Regulatory B cells protect against chronic hypoxia‐induced pulmonary hypertension by modulating the Tfh/Tfr immune balance
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13589
Abstract: Hypoxia‐induced pulmonary hypertension (HPH) is a progressive and lethal disease characterized by the uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) and obstructive vascular remodelling. Previous research demonstrated that Breg cells were involved in… read more here.
Keywords: pulmonary hypertension; chronic hypoxia; hypoxia; breg cells ... See more keywords
Suppressing Sjögren syndrome
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DOI: 10.1126/science.357.6352.656-l
Abstract: Autoimmunity T follicular regulatory (Tfr) cells regulate antibody production in the germinal center. Individuals with the autoimmune disease Sjogren syndrome have increased numbers of circulating Tfr cells. Fonseca et al. found that blood and tissue… read more here.
Keywords: gren syndrome; tfr cells; blood tfr; suppressing gren ... See more keywords
AB0035 THE CHARACTERISTICS OF CIRCULATING FOLLICULAR T LYMPHOCYTE SUBSETS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND THE EFFECT OF TFR/TFH BALANCE ON DISEASE ACTIVITY
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.3302
Abstract: Background Rheumatoid arthritis (RA) is a highly disabling autoimmune disease. T lymphocyte subsets imbalance causeing immune dysfunction is essential stages in the occurrence and development of RA diseases. Recent studies show that the interaction of… read more here.
Keywords: tfr cells; tfr tfh; disease; correlation ... See more keywords
Imbalance of Circulatory T Follicular Helper and T Follicular Regulatory Cells in Patients with ANCA-Associated Vasculitis
Sign Up to like & getrecommendations! Published in 2019 at "Mediators of Inflammation"
DOI: 10.1155/2019/8421479
Abstract: Antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is characterized by small-vessel inflammation in association with autoantibodies. Balance between T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells is critical for humoral immune responses.… read more here.
Keywords: follicular helper; tfh tfr; associated vasculitis; tfr ... See more keywords
Treatments for Periductal Mastitis: Systematic Review and Meta-Analysis
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DOI: 10.1159/000514419
Abstract: Introduction: Periductal mastitis (PDM) is a complex benign breast disease with a prolonged course and a high risk of recurrence after treatment. There are many available treatments for PDM, but none is widely accepted. This… read more here.
Keywords: patients treated; treatment; excision; incision ... See more keywords
Treatment-Free Remission in Real-World Chronic Myeloid Leukemia Patients: Insights from German Hematology Practices
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DOI: 10.1159/000525935
Abstract: Introduction: Treatment-free remission (TFR) is increasingly considered as treatment goal for patients with chronic myeloid leukemia (CML), but information on the disposition and outcome of TFR in clinical practice is scarce. Here, we report the… read more here.
Keywords: treatment free; free remission; hematology; treatment ... See more keywords
Study of Treatment-Free Remission Evaluation in Real-World Chronic Myeloid Leukemia; Cost-Effectiveness Analysis
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-116422
Abstract: Chronic myeloid leukemia (CML) needs taking life-long tyrosine kinase inhibitor (TKI) which arises serious toxicities such as peripheral occlusive disease and pulmonary hypertension as well as low-grade toxicities. Treatment-free remission (TFR) can make almost half… read more here.
Keywords: age age; age; treatment; cost ... See more keywords