Identification of Human Blood and Tissue T Follicular Regulatory (Tfr) Cells by Flow Cytometry.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1736-6_4
Abstract: T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells are crucially involved in the regulation of germinal center reactions. Thus, as key players, the assessment of these cell subsets is necessary for a… read more here.
Keywords: regulatory tfr; follicular regulatory; tfr cells; flow cytometry ... See more keywords
Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice
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DOI: 10.1016/j.celrep.2022.110399
Abstract: Follicular helper T (Tfh) cells promote, whereas follicular regulatory T (Tfr) cells restrain, germinal center (GC) reactions. However, the precise roles of these cells in the complex GC reaction remain poorly understood. Here, we perturb… read more here.
Keywords: sars cov; vaccination; germinal center; tfr cells ... See more keywords
The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.07.004
Abstract: Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE… read more here.
Keywords: tfr cells; tfh; follicular regulatory; ratio ... See more keywords
Acute inflammatory arthritis: Methotrexate for chronic chikungunya arthritis?
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2018.21
Abstract: T cells in blood mark Sjögren syndrome activity Blood T follicular regulatory (TFR) cells and T follicular helper (TFH) cells could serve as biomarkers of ectopic lymphoid activity in primary Sjögren syndrome (pSS). In 16… read more here.
Keywords: acute inflammatory; tfr cells; cells blood; tfh cells ... See more keywords
T follicular helper cells and T follicular regulatory cells in rheumatic diseases
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-019-0254-2
Abstract: As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in diagnosis for decades. However, the immunological mechanism underlying their generation has only become clear following the identification of T follicular helper (TFH) cells… read more here.
Keywords: tfr cells; rheumatic diseases; follicular regulatory; tfh cells ... See more keywords
Association of follicular helper T and follicular regulatory T cells with severity and hyperglycemia in hospitalized COVID-19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2047506
Abstract: ABSTRACT We aimed to determine the levels of follicular helper T (Tfh) and follicular regulatory T (Tfr) cells in COVID-19 patients and determine whether their levels correlated with disease severity and presence of hyperglycemia. This… read more here.
Keywords: follicular helper; covid patients; tfr cells; tfh ... See more keywords
ICOS+ follicular regulatory T cells are implicated in the pathogenesis of ulcerative colitis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13568
Abstract: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with a rising incidence worldwide. The precise aetiology is unclear, but aberrant regulatory T cell (Treg) responses have been documented in active UC patients. Follicular regulatory… read more here.
Keywords: icos; tfr cells; anti cd3; follicular regulatory ... See more keywords
Dysregulation of Circulating Tfr/Tfh Ratio in Primary biliary cholangitis
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12616
Abstract: Follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are critical for the development and maintenance of germinal centre (GC) and humoral immune responses. Accumulating evidence has demonstrated that the dysregulation of either… read more here.
Keywords: tfr cells; tfr tfh; pbc; tfh ... See more keywords
Suppressing Sjögren syndrome
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DOI: 10.1126/science.357.6352.656-l
Abstract: Autoimmunity T follicular regulatory (Tfr) cells regulate antibody production in the germinal center. Individuals with the autoimmune disease Sjogren syndrome have increased numbers of circulating Tfr cells. Fonseca et al. found that blood and tissue… read more here.
Keywords: gren syndrome; tfr cells; blood tfr; suppressing gren ... See more keywords
AB0035 THE CHARACTERISTICS OF CIRCULATING FOLLICULAR T LYMPHOCYTE SUBSETS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND THE EFFECT OF TFR/TFH BALANCE ON DISEASE ACTIVITY
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.3302
Abstract: Background Rheumatoid arthritis (RA) is a highly disabling autoimmune disease. T lymphocyte subsets imbalance causeing immune dysfunction is essential stages in the occurrence and development of RA diseases. Recent studies show that the interaction of… read more here.
Keywords: tfr cells; tfr tfh; disease; correlation ... See more keywords
THU0231 IL-2 DRIVES THE CONVERSION OF T FOLLICULAR HELPER TO T FOLLICULAR REGULATORY CELLS THROUGH EPIGENETIC MODIFICATION IN SYSTEMIC LUPUS ERYTHEMATOSUS
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.651
Abstract: Background: Systemic lupus erythematosus (SLE) is a complex polygenic autoimmune disease characterized by immune-system aberrations. Among several types of immune cells, T follicular helper (Tfh) cells promote autoantibody production, whereas T follicular regulatory (Tfr) cells… read more here.
Keywords: tfh; follicular regulatory; tfr cells; follicular helper ... See more keywords