Chlorogenic acid depresses cellular bioenergetics to suppress pancreatic carcinoma through modulating c‐Myc‐TFR1 axis
Sign Up to like & getrecommendations! Published in 2020 at "Phytotherapy Research"
DOI: 10.1002/ptr.6971
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is severe malignant tumor in human, the outcomes of PDAC is extremely poor. Here, we evaluated the potential anti‐tumor activity of chlorogenic Acid (CA) in PDAC. Here, we found CA was… read more here.
Keywords: tfr1; pdac; myc tfr1; cellular bioenergetics ... See more keywords
Structure prediction of transferrin receptor protein 1 (TfR1) by homology modelling, docking, and molecular dynamics simulation studies
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03221
Abstract: Transferrin receptor protein 1 (TfR1) is an important molecule in anti-cancer therapy. Targeted delivery of such therapeutic compounds improves their cellular uptake and circulation time, thereby enhancing therapeutic efficacy. Drug designing is therefore used to… read more here.
Keywords: protein; tfr1; molecular dynamics; transferrin receptor ... See more keywords
Transferrin Receptor Protein 1 Is an Entry Factor for Rabies Virus
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.01612-22
Abstract: For most viruses, cell entry involves engagement with many distinct plasma membrane components, each of which is essential. After binding to its specific receptor(s), rabies virus (RABV) enters host cells through the process of clathrin-mediated… read more here.
Keywords: entry; tfr1; rabv; rabies virus ... See more keywords
Abstract 3631: Delivery of a CD20 transferrin receptor VNAR bispecific antibody to the brain for CNS lymphoma
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DOI: 10.1158/1538-7445.am2017-3631
Abstract: Penetration of the blood brain barrier (BBB) remains a significant hurdle in the development of biologic therapeutics for CNS-related cancers. Antibody-based molecules typically do not cross the BBB in amounts required for therapeutic efficacy. Receptor-mediated… read more here.
Keywords: tfr1; delivery; receptor; cd20 ... See more keywords
Use of Ppmx-T003 As a Potent Inhibitor of Erythrocytosis in Polycythemia Vera
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DOI: 10.1182/blood-2020-138387
Abstract: Iron incorporation through transferrin (Tf) and its receptor, TfR1, plays a critical role in erythropoiesis. We hypothesized that blockade of TfR1 may be a promising strategy to suppress erythrocytosis observed in polycythemia vera (PV). To… read more here.
Keywords: tfr1; ppmx t003; ltd; japan ... See more keywords
Leucine zipper transcription factor-like 1 binds adaptor protein complex-1 and 2 and participates in trafficking of transferrin receptor 1
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DOI: 10.1371/journal.pone.0226298
Abstract: LZTFL1 participates in immune synapse formation, ciliogenesis, and the localization of ciliary proteins, and knockout of LZTFL1 induces abnormal distribution of heterotetrameric adaptor protein complex-1 (AP-1) in the Lztfl1-knockout mouse photoreceptor cells, suggesting that LZTFL1… read more here.
Keywords: tfr1; protein complex; lztfl1; adaptor protein ... See more keywords
Identification of a Novel Inhibitor of TfR1 from Designed and Synthesized Muriceidine A Derivatives
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DOI: 10.3390/antiox11050834
Abstract: The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf. TfR1 is often reported to be overexpressed in malignant cells, and this increase may be associated… read more here.
Keywords: unsaturated piperidine; muriceidine; muriceidine derivatives; designed synthesized ... See more keywords
Efficacy of Antibodies Targeting TfR1 in Xenograft Mouse Models of AIDS-Related Non-Hodgkin Lymphoma
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DOI: 10.3390/cancers15061816
Abstract: Simple Summary There is an increased risk for the development of certain cancers, including non-Hodgkin lymphoma (NHL), in individuals infected with the human immunodeficiency virus (HIV). Therefore, NHL is considered to be an acquired immunodeficiency… read more here.
Keywords: cell; lymphoma; aids nhl; mouse models ... See more keywords
NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.80737
Abstract: Cholangiocarcinoma (CCA) is the second most common primary hepatic malignancy and associated with poor prognosis. Lack of therapeutic methods for CCA and insensitivity of targeted therapy and immunotherapy make its treatment challenging. NUF2, a component… read more here.
Keywords: cca; autophagic degradation; progression; migration ... See more keywords