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   Articles with "tfv" as a keyword



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The effect of depot medroxyprogesterone acetate on tenofovir alafenamide in rhesus macaques

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recommendations! Published in 2020 at "Antiviral research"

DOI: 10.1016/j.antiviral.2020.105001

Abstract: Prevention of HIV infection and unintended pregnancies are public health priorities. In sub-Saharan Africa, where HIV prevalence is highest, depot medroxyprogesterone acetate (DMPA) is widely used as contraception. Therefore, understanding potential interactions between DMPA and… read more here.

Keywords: tissue; depot medroxyprogesterone; tfv; dmpa ... See more keywords
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Development and validation of a liquid chromatography‐MS/MS method for simultaneous quantification of tenofovir and efavirenz in biological tissues and fluids

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recommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"

DOI: 10.1016/j.jpba.2016.12.028

Abstract: &NA; Millions of people worldwide live with human immunodeficiency virus (HIV) infection thus justifying the continuous search for new prevention and treatment strategies, including topical microbicide products combining antiretroviral drugs (ARVs) such as tenofovir (TFV)… read more here.

Keywords: tissues fluids; tenofovir; method; tfv ... See more keywords
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Validation and implementation of liquid chromatographic‐mass spectrometric (LC–MS) methods for the quantification of tenofovir prodrugs

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recommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"

DOI: 10.1016/j.jpba.2018.02.011

Abstract: Background: The nucleotide reverse transcriptase inhibitor tenofovir (TFV) is widely administered in a disoproxil prodrug form (tenofovir disoproxil fumarate, TDF) for HIV management and prevention. Recently, novel prodrugs tenofovir alafenamide fumarate (TAF) and hexadecyloxypropyl tenofovir… read more here.

Keywords: tenofovir; taf tfv; mass; tfv ... See more keywords
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Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-25690-5

Abstract: Treatment and prevention of human immunodeficiency virus type one (HIV-1) infection was transformed through widespread use of antiretroviral therapy (ART). However, ART has limitations in requiring life-long daily adherence. Such limitations have led to the… read more here.

Keywords: long acting; nm1tfv nm2tfv; stable protide; tfv ... See more keywords
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Tenofovir Inhibits Wound Healing of Epithelial Cells and Fibroblasts from the Upper and Lower Human Female Reproductive Tract

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep45725

Abstract: Disruption of the epithelium in the female reproductive tract (FRT) is hypothesized to increase HIV infection risk by interfering with barrier protection and facilitating HIV-target cell recruitment. Here we determined whether Tenofovir (TFV), used vaginally… read more here.

Keywords: wound healing; epithelial cells; tfv; female reproductive ... See more keywords
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Short Communication: Bioequivalence of Tenofovir Component of Tenofovir/Rilpivirine/Emtricitabine in Digital Pills.

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recommendations! Published in 2019 at "AIDS research and human retroviruses"

DOI: 10.1089/aid.2018.0073

Abstract: Digital pills, gelatin capsules with radiofrequency transmitters activated by stomach chloride ions, directly measure antiretroviral therapy adherence. In individuals with substance use disorders and HIV, real-time nonadherence detected by digital pills creates a platform to… read more here.

Keywords: digital pill; bioequivalence tenofovir; tfv; rilpivirine ... See more keywords
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Tenofovir-Diphosphate in Dried Blood Spots vs Tenofovir in Urine/Plasma for Oral Preexposure Prophylaxis Adherence Monitoring

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recommendations! Published in 2022 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofac405

Abstract: Abstract Background Tenofovir-diphosphate (TFV-DP) measured in dried blood spots (DBS) and tenofovir (TFV) measured in urine/plasma have been used to measure TFV-based oral pre-exposure prophylaxis (PrEP) adherence. However, there are limited data comparing these 3… read more here.

Keywords: adherence; tfv; dried blood; urine plasma ... See more keywords
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Changes in Adenoma Detection Rate From Full-Spectrum Endoscopy to Standard Forward-Viewing Endoscopy.

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recommendations! Published in 2022 at "Journal of clinical gastroenterology"

DOI: 10.1097/mcg.0000000000001706

Abstract: GOALS The aim was to investigate the adenoma detection rate (ADR) of endoscopists who have used full-spectrum endoscopy (Fuse) for 3 years and revert back to traditional forward-viewing endoscopes (R-TFV) at an ambulatory surgical center.… read more here.

Keywords: fuse; tfv fuse; forward viewing; tfv ... See more keywords

Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate

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recommendations! Published in 2022 at "Drug Metabolism and Disposition"

DOI: 10.1124/dmd.122.000855

Abstract: Tenofovir (TFV; prescribed as TFV disoproxil fumarate and TFV alafenamide prodrugs) is currently used for HIV prevention and treatment. TFV must be phosphorylated twice into TFV-diphosphate (TFV-DP) to become pharmacologically active. Previously, we reported heterogeneity… read more here.

Keywords: dephosphorylation; ntpdase; tfv; colorectal tissue ... See more keywords
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Predicting Pharmacokinetics of a Tenofovir Alafenamide Subcutaneous Implant Using Physiologically Based Pharmacokinetic Modelling

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recommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00155-20

Abstract: Long-acting (LA) administration using a subcutaneous (s.c.) implant presents opportunities to simplify administration of antiretroviral drugs, improve pharmacological profiles, and overcome suboptimal adherence associated with daily oral formulations. Tenofovir alafenamide (TAF) is a highly potent… read more here.

Keywords: administration; physiologically based; tenofovir alafenamide; subcutaneous implant ... See more keywords
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Pharmacokinetic Model of Tenofovir and Emtricitabine and Their Intracellular Metabolites in Patients in the ANRS 134-COPHAR 3 Trial Using Dose Records

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recommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.02339-18

Abstract: Tenofovir (TFV) and emtricitabine (FTC) are part of the recommended highly active antiretroviral therapy (ART). Both molecules show a large interindividual pharmacokinetic (PK) variability. ABSTRACT Tenofovir (TFV) and emtricitabine (FTC) are part of the recommended… read more here.

Keywords: tenofovir; intracellular metabolites; tfv; model ... See more keywords