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Published in 2021 at "Blood Cancer Journal"
DOI: 10.1038/s41408-021-00436-0
Abstract: The constitutive activation of B-cell receptor (BCR) signaling, together with the overexpression of the Bcl-2 family anti-apoptotic proteins, represents two hallmarks of chronic lymphocytic leukemia (CLL) that drive leukemia cell proliferation and sustain their survival.…
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Keywords:
apoptosis;
kinase;
cell receptor;
tg02 ... See more keywords
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Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.104
Abstract: Therapies targeting multiple survival pathways are desirable for high-grade gliomas. TG02 (Zotiraciclib), a CDK9 inhibitor, regulates transcription and metabolism of tumor cells and synergizes with temozolomide. A phase I/II trial was launched to test the…
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Keywords:
dose level;
recurrent high;
tg02;
high grade ... See more keywords