Transglutaminase 2 affinity and enzyme‐substrate intermediate stability as determining factors for T‐cell responses to gluten peptides in celiac disease
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249862
Abstract: The adaptive immune response of celiac disease (CeD) involves presentation of gluten peptides to CD4+ T cells by transglutaminase 2 (TG2) specific B cells. This B‐cell/T‐cell crosstalk is facilitated by involvement of TG2:gluten peptide complexes… read more here.
Keywords: gluten peptides; celiac disease; specific cells; tg2 specific ... See more keywords
Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23356
Abstract: Type 2 transglutaminase (TG2) functions as an important cancer cell survival protein in a range of cancers including epidermal squamous cell carcinoma. TG2 exists in open and closed conformations each of which has a distinct… read more here.
Keywords: protein; tg2; conformation; gtp binding ... See more keywords
TGFβ1-Induced Transglutaminase-2 Triggers Catabolic Response in Osteoarthritic Chondrocytes by Modulating MMP-13.
Sign Up to like & getrecommendations! Published in 2021 at "Tissue engineering and regenerative medicine"
DOI: 10.1007/s13770-021-00342-3
Abstract: BACKGROUND Transforming growth factor beta 1 (TGFβ1) plays an essential role in maintaining cartilage homeostasis. TGFβ1 is known to upregulate anabolic processes in articular cartilage, but the role of TGFβ1 in chondrocyte catabolism remains unclear.… read more here.
Keywords: tg2; mmp; tgf; tgf tg2 ... See more keywords
Transglutaminase 2 modulation of NF-κB signaling in astrocytes is independent of its ability to mediate astrocytic viability in ischemic injury
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.05.009
Abstract: Transglutaminase 2 (TG2) is a multifunctional protein that can contribute to cell death and cell survival processes in a variety of disease contexts. Within the brain, TG2 has been shown to promote cell death in… read more here.
Keywords: tg2; viability; ability mediate; ischemic injury ... See more keywords
Transglutaminase 2 Depletion Attenuates α-Synuclein Mediated Toxicity in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.05.047
Abstract: α-Synuclein (α-Syn) is a key pathogenic protein in α-synucleinopathies including Parkinson disease (PD) and Dementia with Lewy Bodies. The aggregation of α-Syn is believed to be deleterious and a critical step leading to neuronal dysfunction… read more here.
Keywords: tg2; toxicity; syntg mice; mice ... See more keywords
Transglutaminase 2 as a therapeutic target for neurological conditions.
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on therapeutic targets"
DOI: 10.1080/14728222.2021.1989410
Abstract: INTRODUCTION : Transglutaminase 2 (TG2) has been implicated in numerous neurological conditions, including neurodegenerative diseases, multiple sclerosis, and CNS injury. Early studies on the role of TG2 in neurodegenerative conditions focused on its ability to… read more here.
Keywords: tg2; tg2 inhibitors; neurodegenerative diseases; sclerosis cns ... See more keywords
Transglutaminase 2 in chronic inflammation and fibrosis – a potential novel therapy for stricturing Crohn’s disease
Sign Up to like & getrecommendations! Published in 2025 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2025.2585345
Abstract: ABSTRACT Introduction In inflammatory bowel diseases (IBD), human intestinal myofibroblasts (HIMF) gets activated due to chronic inflammation and start accumulating excessive extracellular matrix (ECM). ECM drives the significant clinical problem of intestinal fibrosis and stricture… read more here.
Keywords: crohn disease; chronic inflammation; fibrosis; tg2 ... See more keywords
P117 Transglutaminase 2 is elevated in Crohn’s disease associated strictures and exerts profibrotic activities in myofibroblasts and experimental intestinal fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjad212.0247
Abstract: Intestinal fibrosis is a significant clinical problem in Inflammatory bowel disease (IBD). This may lead to intestinal strictures induced by excessive accumulation of extracellular matrix (ECM) produced by human intestinal myofibroblasts (HIMF). Transglutaminase (TG)2 covalently… read more here.
Keywords: transglutaminase; fibrosis; crohn disease; intestinal fibrosis ... See more keywords
Targeting transglutaminase 2: pathways to celiac disease therapies
Sign Up to like & getrecommendations! Published in 2025 at "Gastroenterology Report"
DOI: 10.1093/gastro/goaf086
Abstract: Abstract Background Transglutaminase 2 (TG2)-mediated enzymatic modification of gliadin peptides plays a major role in the pathogenesis of celiac disease (CD). Different inhibitory mechanisms have been reported to reduce TG2 activity but comparative data on… read more here.
Keywords: transglutaminase; celiac disease; tg2 activity; tg2 ... See more keywords
Metformin prevents hypoxia‐induced podocyte injury by regulating the ZEB2/TG2 axis
Sign Up to like & getrecommendations! Published in 2022 at "Nephrology"
DOI: 10.1111/nep.14121
Abstract: Podocytes, a vital component of the glomerular filtration barrier, are vulnerable to various noxious stimuli, including Hypoxic. HIF1α that transduces hypoxic adaptations induces Transglutaminase 2 (TG2), which catalyses cross‐linking of extracellular matrix proteins. In this… read more here.
Keywords: hypoxia induced; metformin prevents; induced podocyte; podocyte injury ... See more keywords
Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002682
Abstract: Background Tissue transglutaminase (TG2), an enzyme overexpressed in cancer cells, promotes metastasis and resistance to chemotherapy. Its distinct effects in cancer versus the host compartments have not been elucidated. Methods Here, by using a TG2-/-… read more here.
Keywords: tumor; tg2; host; cancer ... See more keywords