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Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249862
Abstract: The adaptive immune response of celiac disease (CeD) involves presentation of gluten peptides to CD4+ T cells by transglutaminase 2 (TG2) specific B cells. This B‐cell/T‐cell crosstalk is facilitated by involvement of TG2:gluten peptide complexes…
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Keywords:
gluten peptides;
celiac disease;
specific cells;
tg2 specific ... See more keywords
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Published in 2021 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23356
Abstract: Type 2 transglutaminase (TG2) functions as an important cancer cell survival protein in a range of cancers including epidermal squamous cell carcinoma. TG2 exists in open and closed conformations each of which has a distinct…
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Keywords:
protein;
tg2;
conformation;
gtp binding ... See more keywords
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Published in 2021 at "Tissue engineering and regenerative medicine"
DOI: 10.1007/s13770-021-00342-3
Abstract: BACKGROUND Transforming growth factor beta 1 (TGFβ1) plays an essential role in maintaining cartilage homeostasis. TGFβ1 is known to upregulate anabolic processes in articular cartilage, but the role of TGFβ1 in chondrocyte catabolism remains unclear.…
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Keywords:
tg2;
mmp;
tgf;
tgf tg2 ... See more keywords
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Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.05.009
Abstract: Transglutaminase 2 (TG2) is a multifunctional protein that can contribute to cell death and cell survival processes in a variety of disease contexts. Within the brain, TG2 has been shown to promote cell death in…
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Keywords:
tg2;
viability;
ability mediate;
ischemic injury ... See more keywords
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Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.05.047
Abstract: α-Synuclein (α-Syn) is a key pathogenic protein in α-synucleinopathies including Parkinson disease (PD) and Dementia with Lewy Bodies. The aggregation of α-Syn is believed to be deleterious and a critical step leading to neuronal dysfunction…
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Keywords:
tg2;
toxicity;
syntg mice;
mice ... See more keywords
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Published in 2021 at "Expert opinion on therapeutic targets"
DOI: 10.1080/14728222.2021.1989410
Abstract: INTRODUCTION : Transglutaminase 2 (TG2) has been implicated in numerous neurological conditions, including neurodegenerative diseases, multiple sclerosis, and CNS injury. Early studies on the role of TG2 in neurodegenerative conditions focused on its ability to…
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Keywords:
tg2;
tg2 inhibitors;
neurodegenerative diseases;
sclerosis cns ... See more keywords
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Published in 2022 at "Nephrology"
DOI: 10.1111/nep.14121
Abstract: Podocytes, a vital component of the glomerular filtration barrier, are vulnerable to various noxious stimuli, including Hypoxic. HIF1α that transduces hypoxic adaptations induces Transglutaminase 2 (TG2), which catalyses cross‐linking of extracellular matrix proteins. In this…
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Keywords:
hypoxia induced;
metformin prevents;
induced podocyte;
podocyte injury ... See more keywords
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Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002682
Abstract: Background Tissue transglutaminase (TG2), an enzyme overexpressed in cancer cells, promotes metastasis and resistance to chemotherapy. Its distinct effects in cancer versus the host compartments have not been elucidated. Methods Here, by using a TG2-/-…
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Keywords:
tumor;
tg2;
host;
cancer ... See more keywords
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Published in 2018 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2017-0720
Abstract: Tissue transglutaminase (TG2) plays an important role in pulmonary arterial hypertension (PAH). Previous research indicate that TG2 and protein serotonylation catalyzed by TG2 are upregulated in PAH. Serotonin transporter inhibitor fluoxetine ameliorates PAH via inhibition…
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Keywords:
monocrotaline;
tg2;
pulmonary arterial;
monocrotaline induced ... See more keywords
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Published in 2021 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-21-0306
Abstract: Transglutaminase 2 (TG2) is a key epidermal squamous cell carcinoma cancer cell survival protein. However, how TG2 maintains the aggressive cancer phenotype is not well understood. The present studies show that TG2, which is highly…
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Keywords:
tg2;
cancer phenotype;
cancer;
cell ... See more keywords
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Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0266543
Abstract: Background Celiac disease is an autoimmune enteropathy driven by dietary intake of gluten proteins. Typical histopathologic features are villous flattening, crypt hyperplasia and infiltration of inflammatory cells in the intestinal epithelium and lamina propria. The…
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Keywords:
tg2;
transglutaminase;
prototypic celiac;
celiac ... See more keywords