Cognitive decline in Tg2576 mice shows sex-specific differences and correlates with cerebral amyloid-beta
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.11.022
Abstract: HighlightsTg2576 mice develop cognitive impairment beginning at the age of 8 months.Female Tg2576 mice show worse reference memory than males at 12–16 months.Cognitive impairment is sex‐dependently correlated to A&bgr; (soluble and deposits). Abstract Patients suffering… read more here.
Keywords: amyloid beta; cognitive impairment; tg2576 mice; mice ... See more keywords
The expression and activity of KV3.4 channel subunits are precociously upregulated in astrocytes exposed to Aβ oligomers and in astrocytes of Alzheimer's disease Tg2576 mice
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.03.008
Abstract: Astrocyte dysfunction emerges early in Alzheimer's disease (AD) and may contribute to its pathology and progression. Recently, the voltage gated potassium channel KV3.4 subunit, which underlies the fast-inactivating K+ currents, has been recognized to be… read more here.
Keywords: tg2576 mice; expression; channel subunits; kv3 ... See more keywords
Synaptic Correlates of Anterograde Amnesia and Intact Retrograde Memory in a Mouse Model of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Current Alzheimer research"
DOI: 10.2174/1567205017666200224122113
Abstract: BACKGROUND Clinical evidence indicates that patients affected by Alzheimer's Disease (AD) fail to form new memories although their memories for old events are intact. This amnesic pattern depends on the selective vulnerability to AD-neurodegeneration of… read more here.
Keywords: new memories; alzheimer disease; tg2576 mice; mouse model ... See more keywords
Pharmacological enhancement of slow-wave activity at an early disease stage improves cognition and reduces amyloid pathology in a mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2024.1519225
Abstract: Introduction Improving sleep in murine Alzheimer’s disease (AD) is associated with reduced brain amyloidosis. However, the window of opportunity for successful sleep-targeted interventions, regarding the reduction in pathological hallmarks and related cognitive performance, remains poorly… read more here.
Keywords: alzheimer disease; disease; tg2576 mice; slow wave ... See more keywords