Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours
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DOI: 10.1136/ard-2022-223470
Abstract: Objectives CHRFAM7A is a uniquely human fusion gene that functions as a dominant negative regulator of alpha 7 acetylcholine nicotinic receptor (α7nAChR) in vitro. This study determined the impact of CHRFAM7A on α7nAChR agonist responses,… read more here.
Keywords: gene; tgchrfam7a mice; pain behaviours; mice ... See more keywords