Serum levels of the IgA isotype switch factor TGF‐β1 are elevated in patients with COVID‐19
Sign Up to like & getrecommendations! Published in 2021 at "Febs Letters"
DOI: 10.1002/1873-3468.14104
Abstract: We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID‐19, which might confer damaging effects. Given the important role of IgA in immune and inflammatory responses, the aim of this study was to investigate… read more here.
Keywords: switch factor; isotype switch; covid; tgf ... See more keywords
TGFβ instructs mTORC2 to activate PKCβII for increased TWIST1 expression in proximal tubular epithelial cell injury
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14599
Abstract: The plasticity of proximal tubular epithelial cells in response to TGFβ contributes to the expression of TWIST1 to drive renal fibrosis. The mechanism of TWIST1 expression is not known. We show that both PI3 kinase… read more here.
Keywords: cell; proximal tubular; expression; twist1 expression ... See more keywords
TGF‐β transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12162
Abstract: Transforming growth factor‐beta (TGF‐β) functions as a potent proliferation inhibitor and apoptosis inducer in the early stages of breast cancer, yet promotes cancer aggressiveness in the advanced stages. The dual effect of TGF‐β on cancer… read more here.
Keywords: signaling pathways; canonical smad3; breast cancer; tgf ... See more keywords
Fibroblast growth factor signals regulate transforming growth factor‐β‐induced endothelial‐to‐myofibroblast transition of tumor endothelial cells via Elk1
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12504
Abstract: The tumor microenvironment contains various components, including cancer cells, tumor vessels, and cancer‐associated fibroblasts, the latter of which are comprised of tumor‐promoting myofibroblasts and tumor‐suppressing fibroblasts. Multiple lines of evidence indicate that transforming growth factor‐β… read more here.
Keywords: growth factor; tgf; endothelial cells; growth ... See more keywords
LAMC1 upregulation via TGFβ induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-κB-CXCL1-STAT3.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13053
Abstract: Cancer-associated fibroblasts (CAFs) are a heterogenous cell population within the tumor microenvironment, and play an important role in tumor development. By regulating the heterogeneity of CAFs, transforming growth factor β (TGFβ) influences tumor development. Here,… read more here.
Keywords: associated fibroblasts; tgf; cancer associated; cell ... See more keywords
TGFβ selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13215
Abstract: Transforming growth factor β (TGFβ) induces epithelial-mesenchymal transition (EMT), which correlates with stemness and invasiveness. Mesenchymal-epithelial transition (MET) is induced by TGFβ withdrawal and correlates with metastatic colonization. Whether TGFβ promotes stemness and invasiveness simultaneously… read more here.
Keywords: mesenchymal transition; cancer cell; tgf; pro stemness ... See more keywords
Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104469
Abstract: Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists. The available therapies for tendinopathy are limited in number and efficacy and… read more here.
Keywords: inhibition integrin; activation tgf; tgf; activation ... See more keywords
Local Release of TGF‐β Inhibitor Modulates Tumor‐Associated Neutrophils and Enhances Pancreatic Cancer Response to Combined Irreversible Electroporation and Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105240
Abstract: Pancreatic cancer is a deadly disease with little response to standard therapies. Irreversible electroporation (IRE) has emerged as a novel ablative technique for the clinical treatment of pancreatic cancer. Combinations of IRE and immunotherapies, including… read more here.
Keywords: response; pancreatic cancer; enhances pancreatic; irreversible electroporation ... See more keywords
Transforming Growth Factor Beta Promotes Inflammation and Tumorigenesis in Smad4-Deficient Intestinal Epithelium in a YAP-Dependent Manner.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300708
Abstract: Transforming growth factor beta (TGF-β), a multifunctional cytokine, plays critical roles in immune responses. However, the precise role of TGF-β in colitis and colitis-associated cancer remains poorly defined. Here, it is demonstrated that TGF-β promotes… read more here.
Keywords: transforming growth; tumorigenesis; smad4 deficient; yap ... See more keywords
Vanillin attenuates thioacetamide‐induced renal assault by direct and indirect mediation of the TGFβ, ERK and Smad signalling pathways in rats
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3686
Abstract: Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD). Renal fibrosis is considered to be one of the most important conditions, as it may be the result of excessive extracellular matrix protein… read more here.
Keywords: vanillin attenuates; kidney; induced renal; smad ... See more keywords
Modulation of CD11c+ lung dendritic cells in respect to TGF‐β in experimental pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10800
Abstract: Idiopathic pulmonary fibrosis (IPF) is a deadly, progressive lung disease with very few treatment options till now. Bleomycin‐induced pulmonary fibrosis (BIPF) is a commonly used mice model in IPF research. TGF‐β1 has been shown to… read more here.
Keywords: cd11c; dcs; tgf; pulmonary fibrosis ... See more keywords