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   Articles with "tgf bgr" as a keyword



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The role of pro‐fibrotic biomarkers in paroxysmal and persistent atrial fibrillation

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recommendations! Published in 2018 at "Cytokine"

DOI: 10.1016/j.cyto.2017.12.026

Abstract: Purpose Signaling pathways involved in electrical, structural and contractile remodeling processes behind development and progression of atrial fibrillation (AF) have not been completely elucidated, but it seems to be related to complex interactions among neurohormonal… read more here.

Keywords: atrial fibrillation; bgr; paroxysmal persistent; tgf bgr ... See more keywords
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Impaired TGF‐&bgr; signaling in patients with active systemic lupus erythematosus is associated with an overexpression of IL‐22

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recommendations! Published in 2018 at "Cytokine"

DOI: 10.1016/j.cyto.2018.04.011

Abstract: HighlightsThe transcription of TGF‐&bgr; target genes is impaired in CD3+ lymphocytes of active SLE patients.The TGF‐&bgr; signaling defect did not result from an impaired TGF‐&bgr;RII expression or Smad2/3 phosphorylation.The TGF‐&bgr; signaling defect did not correlate… read more here.

Keywords: overexpression; bgr; bgr signaling; sle patients ... See more keywords

Transforming growth factor‐&bgr;1 impairs lymph node homing of dendritic cells by downregulating C‐type lectin receptor‐2 expression

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recommendations! Published in 2018 at "Cytokine"

DOI: 10.1016/j.cyto.2018.04.023

Abstract: HighlightsTGF‐&bgr;1 impedes DC migration to regional lymph nodes by reducing CLEC‐2 expression.TGF‐&bgr;1 downregulates CLEC‐2 expression in DCs via c‐Src.c‐Src silencing improves lymph node homing of TGF‐&bgr;1‐treated DCs restoring CLEC‐2 level. &NA; Trafficking of dendritic cells… read more here.

Keywords: bgr; node homing; expression; lymph node ... See more keywords
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The imbalance of peripheral interleukin‐18 and transforming growth factor‐&bgr;1 levels in patients with cirrhosis and esophageal varices

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recommendations! Published in 2019 at "Cytokine"

DOI: 10.1016/j.cyto.2018.10.024

Abstract: Introduction: The presence of esophageal varices in liver cirrhosis indicates clinically significant portal hypertension (PH), that results from structural and dynamic changes in the liver and systemic circulation including the activation of several fibrotic and… read more here.

Keywords: bgr; transforming growth; esophageal varices; bgr levels ... See more keywords
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Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2/ARE and TGF‐&bgr;/ smads pathways in rat heart

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recommendations! Published in 2018 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2017.12.013

Abstract: ABSTRACT Left ventricular hypertrophy is more commonly associated with hemodynamic overload imposed by hypertension or volume overload. Transforming growth factor &bgr; (TGF‐&bgr;) is involved in the cardiac hypertrophy and fibrosis of the left ventricle. The… read more here.

Keywords: overload; bgr; group; hypertrophy ... See more keywords
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Knockdown of NLRC5 inhibits renal fibroblast activation via modulating TGF‐&bgr;1/Smad signaling pathway

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recommendations! Published in 2018 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2018.03.045

Abstract: &NA; NLRC5, the largest member of the Nucleotide‐binding domain and leucine‐rich repeat (NLR) protein family, is recently proven to be a critical modulator in fibrogenesis. However, the role of NLRC5 in renal fibrosis remains unknown.… read more here.

Keywords: bgr; knockdown nlrc5; renal fibroblast; tgf bgr ... See more keywords
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Topical administration of a ROCK inhibitor prevents anterior subcapsular cataract induced by UV‐B irradiation

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recommendations! Published in 2019 at "Experimental Eye Research"

DOI: 10.1016/j.exer.2019.01.016

Abstract: ABSTRACT The deposition of extracellular matrix (ECM)—which is mainly composed of type I collagen—in anterior subcapsular cataracts (ASCs) during epithelial‐to‐mesenchymal transition (EMT) of lens epithelial cells (LECs) decreases visual function. Transforming growth factor (TGF)‐&bgr; is… read more here.

Keywords: tgf bgr; type collagen; anterior subcapsular; rock ... See more keywords
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T Cell Receptor‐Regulated TGF‐&bgr; Type I Receptor Expression Determines T Cell Quiescence and Activation

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recommendations! Published in 2018 at "Immunity"

DOI: 10.1016/j.immuni.2018.03.025

Abstract: SUMMARY It is unclear how quiescence is enforced in naive T cells, but activation by foreign antigens and self‐antigens is allowed, despite the presence of inhibitory signals. We showed that active transforming growth factor &bgr;… read more here.

Keywords: bgr; quiescence; bgr signaling; receptor ... See more keywords
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Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin‐induced pulmonary fibrosis by inhibiting TGF‐&bgr;1/Smad2 pathways and overexpression of NOX4

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recommendations! Published in 2017 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.04.024

Abstract: Abstract Pulmonary fibrosis, a progressive and lethal lung disease, is a major therapeutic challenge for which new therapeutic strategies are warranted. Schisandrin B (Sch B) and Glycyrrhizic acid (GA) are the principal active ingredients of… read more here.

Keywords: induced pulmonary; pulmonary fibrosis; blm; tgf bgr ... See more keywords
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Telbivudine attenuates UUO‐induced renal fibrosis via TGF‐&bgr;/Smad and NF‐&kgr;B signaling

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recommendations! Published in 2018 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.11.043

Abstract: ABSTRACT Renal fibrosis yields decreased renal function and is a potent contributor to chronic kidney disease (CKD). Telbivudine (LdT) is an anti–hepatitis B virus (HBV) drug that has been found to steadily improve renal function,… read more here.

Keywords: bgr smad; fibrosis; kgr; renal fibrosis ... See more keywords
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Potential ameliorative effects of epigallocatechin‐3‐gallate against testosterone‐induced benign prostatic hyperplasia and fibrosis in rats

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recommendations! Published in 2018 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2018.08.038

Abstract: ABSTRACT Green tea is among the most popular beverages in the world and is an important source of phytoestrogens. Epigallocatechin‐3‐gallate (EGCG) is the major polyphenol in green tea. The aim of this study was to… read more here.

Keywords: tgf bgr; bgr; egcg; prostatic hyperplasia ... See more keywords