Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02522-2
Abstract: Transforming growth factor beta (TGFβ) and programmed death-ligand 1 (PD-L1) are often overproduced in refractory squamous cell carcinoma (SCC). We examined spatial patterns of PD-L1 + cells in mouse and human SCCs and found that… read more here.
Keywords: squamous cell; tgf; tgf blockade; combined tgf ... See more keywords
TGFβ blockade in pancreatic cancer enhances sensitivity to combination chemotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.05.038
Abstract: BACKGROUND AND AIMS TGFβ plays pleiotropic roles in pancreatic cancer including promoting metastasis, attenuating CD8 T cell activation, and enhancing myofibroblast differentiation and deposition of extracellular matrix. However, single-agent TGFβ inhibition has shown limited efficacy… read more here.
Keywords: cell; pancreatic cancer; tgf blockade; chemotherapy ... See more keywords
Dual-responsive nanosystem based on TGF-β blockade and immunogenic chemotherapy for effective chemoimmunotherapy
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DOI: 10.1080/10717544.2022.2069877
Abstract: Abstract The antitumor immune response induced by chemotherapy has attracted considerable attention. However, the immunosuppressive tumor microenvironment hinders the immune activation effect of cancer chemotherapy. TGF-β plays a key role in driving tumor immunosuppression and… read more here.
Keywords: antitumor; tgf blockade; dual responsive; tumor ... See more keywords
TGFβ Blockade Enhances Radiotherapy Abscopal Efficacy Effects in Combination with Anti-PD1 and Anti-CD137 Immunostimulatory Monoclonal Antibodies
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DOI: 10.1158/1535-7163.mct-18-0558
Abstract: Radiotherapy can be synergistically combined with immunotherapy in mouse models, extending its efficacious effects outside of the irradiated field (abscopal effects). We previously reported that a regimen encompassing local radiotherapy in combination with anti-CD137 plus… read more here.
Keywords: tgf blockade; combination; efficacy; anti cd137 ... See more keywords
TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell–Mediated Regression of Pancreatic Cancer
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DOI: 10.1158/1535-7163.mct-18-0850
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains remarkably lethal with a 5-year survival rate of 8%. This is mainly attributed to the late stage of presentation, as well as widespread resistance to conventional therapy. In addition, PDAC… read more here.
Keywords: regression; inhibition; tgf; promote ... See more keywords
Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis.
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DOI: 10.1182/blood.2022017097
Abstract: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by clonal expansion of myeloid cells, notably megakaryocytes (MKs), and aberrant cytokine production leading to bone marrow (BM) fibrosis and insufficiency. Current treatment options are limited. TGF-b1,… read more here.
Keywords: cell; tgf blockade; garp; garp tgf ... See more keywords
Efficacy of therapies targeting TGF-β in solid tumors: a systematic review and meta-analysis of clinical trials.
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DOI: 10.2217/imt-2022-0079
Abstract: Aims: A comprehensive meta-analysis was conducted to explore the efficacy of TGF-β blockade therapies in solid tumors. Patients & methods: Results of overall survival (OS), progression-free survival (PFS), time to progression (TTP) and overall response rate… read more here.
Keywords: tgf blockade; tgf; meta analysis; solid tumors ... See more keywords