Opposing roles and potential antagonistic mechanism between TGF-β and BMP pathways: Implications for cancer progression
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.02.033
Abstract: The transforming growth factor β (TGF-β) superfamily participates in tumour proliferation, apoptosis, differentiation, migration, invasion, immune evasion and extracellular matrix remodelling. Genetic deficiency in distinct components of TGF-β and BMP-induced signalling pathways or their excessive… read more here.
Keywords: bmp pathways; bmp; tgf bmp; opposing roles ... See more keywords
Bta-miR-493 Inhibits Bovine Preadipocytes Differentiation by Targeting BMPR1A via the TGFβ/BMP and p38MAPK Signaling Pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05719
Abstract: Fat deposition significantly impacts the meat yield and the meat quality of beef cattle, which is closely associated with the preadipocyte proliferation and differentiation. Bta-miR-493 is expressed differentially in the backfat of Qinchuan cattle of… read more here.
Keywords: bmpr1a; bta mir; bmp p38mapk; mir 493 ... See more keywords
KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Stroke and Vascular Neurology"
DOI: 10.1136/svn-2022-001700
Abstract: Objective Somatic KRAS mutations have been identified in the majority of brain arteriovenous malformations (bAVMs), and subsequent in vivo experiments have confirmed that KRAS mutation in endothelial cells (ECs) causes AVMs in mouse and zebrafish… read more here.
Keywords: krasg12d; krasg12d mutant; brain arteriovenous; tgf bmp ... See more keywords
Abstract LB232: Imbalance of TGF-β1/BMP-7 pathway induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness
Sign Up to like & getrecommendations! Published in 2021 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2021-lb232
Abstract: The transforming growth factor-beta (TGF-β) signaling represented the predominant cytokine signaling involved in the development and progression of hepatocellular carcinoma (HCC). Bone morphogenetic protein (BMP), another member of TGF-β superfamily, was frequently found to have… read more here.
Keywords: hcc; tgf; imbalance tgf; tgf bmp ... See more keywords
Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-19-0165
Abstract: Functional modeling of normal breast epithelial hierarchy and stromal–epithelial cell interactions have been difficult due to inability to obtain sufficient stem-progenitor-mature epithelial and stromal cells. Recently reported epithelial reprogramming assay has partially overcome this limitation,… read more here.
Keywords: cell types; epithelial cell; cell; breast ... See more keywords
Intradiscal Delivery of Anabolic Growth Factors and a Metalloproteinase Inhibitor in a Rabbit Acute Lumbar Disc Injury Model
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Spine Surgery"
DOI: 10.14444/7078
Abstract: ABSTRACT Background The purpose of our study was to examine the effect of controlled delivery of TGF-β3, BMP-4, and TIMP-2 with a biocompatible biopolymer, chitosan, on an acutely injured intervertebral disc (IVD) in a rabbit… read more here.
Keywords: bmp timp; bmp; rabbit; tgf bmp ... See more keywords
Transforming growth factor-β signalling regulates protoscolex formation in the Echinococcus multilocularis metacestode
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1153117
Abstract: The lethal zoonosis alveolar echinococcosis (AE) is caused by tumor-like, infiltrative growth of the metacestode larval stage of the tapeworm Echinococcus multilocularis. We previously showed that the metacestode is composed of posteriorized tissue and that… read more here.
Keywords: metacestode; echinococcus multilocularis; tgf bmp;
Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076423
Abstract: MicroRNAs (miRNAs) are a family of small, single-stranded, and non-protein coding RNAs about 19 to 22 nucleotides in length, that have been reported to have important roles in the control of bone development. MiRNAs have… read more here.
Keywords: bmp; bmp signalling; signalling cascades; canonical tgf ... See more keywords
High-density human mesenchymal stem cell rings with spatiotemporally-controlled morphogen presentation as building blocks for engineering bone diaphyseal tissue
Sign Up to like & getrecommendations! Published in 2018 at "Nanotheranostics"
DOI: 10.7150/ntno.23354
Abstract: Emerging biomimetic tissue engineering strategies aim to partially recapitulate fundamental events that transpire during embryonic skeletal development; namely, cellular self-organization and targeted morphogenetic pathway activation. Here, we describe self-assembled, scaffold-free human mesenchymal stem cell (hMSC)… read more here.
Keywords: presentation; bmp; tgf bmp; tissue ... See more keywords