Transforming growth factor‐β family biology: From basic mechanisms to roles in development and disease
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.445
Abstract: The transforming growth factor-β (TGF-β) family of ligands comprises 33 members in humans, of which 30 are positively acting ligands including the TGF-βs, the Activins, the bone morphogenetic proteins (BMPs), the growth and differentiation factors… read more here.
Keywords: growth; biology; family; tgf family ... See more keywords
Establishment of Embryonic Zebrafish Xenograft Assays to Investigate TGF-β Family Signaling in Human Breast Cancer Progression.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2277-3_6
Abstract: Transforming growth factor-β (TGF-β) family members have pivotal functions in controlling breast cancer progression, acting not only on cancer cells but also on other cells within the tumor microenvironment. Here we describe embryonic zebrafish xenograft… read more here.
Keywords: cancer; breast cancer; tgf family; family signaling ... See more keywords
WITHDRAWN: Modulation of adipocyte function by the TGF-β family.
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.05.011
Abstract: This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. read more here.
Keywords: modulation adipocyte; withdrawn; tgf family; function tgf ... See more keywords
Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.07.018
Abstract: GW182 (also known asTNRC6) family members are critically involved in the final effector phase of miRNA-mediated mRNA repression. The three mammalian paralogs, TNRC6a, b and c, are thought to be redundant based on Argonaute (Ago)… read more here.
Keywords: tgf family; tnrc6c mutants; trinucleotide repeat; tnrc6c ... See more keywords
Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2104809118
Abstract: Significance Anti-Müllerian hormone (AMH) plays a crucial role in male sex differentiation and female reproductive development. As such, AMH is widely used as a biomarker for measuring a woman’s fertility, estimating onset of menopause, and… read more here.
Keywords: amhr2; structure amh; amh; tgf family ... See more keywords
Regulation of TGF-β Family Signaling by Inhibitory Smads.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a022095
Abstract: Inhibitory Smads (I-Smads) have conserved carboxy-terminal MH2 domains but highly divergent amino-terminal regions when compared with receptor-regulated Smads (R-Smads) and common-partner Smads (co-Smads). Smad6 preferentially inhibits Smad signaling initiated by the bone morphogenetic protein (BMP)… read more here.
Keywords: regulation tgf; smad signaling; smads smads; family signaling ... See more keywords
Erratum: TGF-β Family Signaling in Drosophila.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a031963
Abstract: The footnote indicating that the first four authors of this article contributed equally was inadvertently dropped during initial page composition. The publisher apologizes for this error. Although the footnote did not appear in the article… read more here.
Keywords: article; erratum tgf; family signaling; tgf family ... See more keywords
Molecular Mechanisms of AMH Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.927824
Abstract: Anti-Müllerian Hormone (AMH) is a secreted glycoprotein hormone with critical roles in reproductive development and regulation. Its chemical and mechanistic similarities to members of the Transforming Growth Factor β (TGF-β) family have led to its… read more here.
Keywords: amh signaling; mechanisms amh; molecular mechanisms; tgf family ... See more keywords