ESE1/AGR2 axis antagonizes TGF‐β‐induced epithelial‐mesenchymal transition in low‐grade pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5397
Abstract: Epithelium‐specific ETS transcription factor 1 (ESE1) has been implicated in epithelial homeostasis, inflammation, as well as tumorigenesis, and cancer progression. However, numerous studies have reported contradictory roles—as an oncogene or a tumor suppressor of ESE1… read more here.
Keywords: mesenchymal transition; tgf induced; ese1; epithelial mesenchymal ... See more keywords
The role of small GTPases of the Rho/Rac family in TGF‐β‐induced EMT and cell motility in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24505
Abstract: This article focuses on the role of Rho family GTPases, particularly Rac1 and Rac1b in TGF‐β‐induced epithelial‐mesenchymal transition (EMT) and EMT‐associated responses such as cell migration, invasion, and metastasis in cancer. EMT is considered a… read more here.
Keywords: family; small gtpases; tgf; role ... See more keywords
The Novel mTOR Complex 1/2 Inhibitor P529 Inhibits Human Lung Myofibroblast Differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25878
Abstract: Idiopathic pulmonary fibrosis is a progressive and deadly disorder with very few therapeutic options. Palomid 529 (8‐(1‐hydroxyethyl)‐2‐methoxy‐3‐(4‐methoxybenzyloxy)‐benzo[c]chromen‐6‐one; P529) is a novel dual inhibitor of mechanistic target of rapamycin complex 1/2 (mTORC1/2). In these studies, we… read more here.
Keywords: myofibroblast differentiation; human lung; tgf induced; p529 ... See more keywords
LncRNA UCA1/miR‐124 axis modulates TGFβ1‐induced epithelial‐mesenchymal transition and invasion of tongue cancer cells through JAG1/Notch signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28334
Abstract: Tongue cancer remains a massive threat to public health due to the high rate of metastasis. Tumor cell epithelial‐mesenchymal transition (EMT), which can be induced by transforming growth factor β1 (TGFβ1), has been regarded as… read more here.
Keywords: invasion; tongue cancer; tgf induced; cancer ... See more keywords
PKM2‐regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF‐β1‐induced EMT
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28434
Abstract: Recent studies have demonstrated pleiotropic roles of pyruvate kinase isoenzyme type M2 (PKM2) in tumor progression. However, the precise mechanisms underlying the effects of PKM2 on esophageal squamous cell carcinoma (ESCC) metastasis and transforming growth… read more here.
Keywords: esophageal squamous; pkm2; expression; tgf induced ... See more keywords
Matrine improves diabetic cardiomyopathy through TGF‐β‐induced protein kinase RNA‐like endoplasmic reticulum kinase signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28632
Abstract: Matrine might play a vital role in cardiovascular diseases progression and treatment. read more here.
Keywords: matrine improves; kinase; cardiomyopathy tgf; improves diabetic ... See more keywords
Foxm1 is a critical driver of TGF‐β‐induced EndMT in endothelial cells through Smad2/3 and binds to the Snail promoter
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27583
Abstract: Endothelial‐to‐mesenchymal transition (EndMT) was first reported in heart development. Recent studies have shown that EndMT also occurs in the progression of cardiac fibrosis. Herein, we demonstrated a critical role of the Forkhead Box M1 (Foxm1)… read more here.
Keywords: driver tgf; endmt endothelial; tgf; endothelial cells ... See more keywords
The Smad2/3/4 complex binds miR‐139 promoter to modulate TGFβ‐induced proliferation and activation of human Tenon's capsule fibroblasts through the Wnt pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28011
Abstract: The activation and proliferation of human Tenon's fibroblasts (HTFs) play a vital role in the fibrosis in the pathology of the scar formation after the glaucoma filtration surgery. Transforming growth factor β1 (TGFβ1)/Smads signaling has… read more here.
Keywords: mir 139; activation proliferation; tgf induced; proliferation ... See more keywords
Visualizing Dynamic Changes During TGF-β-Induced Epithelial to Mesenchymal Transition.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2277-3_5
Abstract: Epithelial to mesenchymal transition (EMT) is crucial during embryonic development, tissue fibrosis, and cancer progression. Epithelial cells that display a cobblestone-like morphology can undergo a switch to mesenchymal-like phenotype, displaying an elongated spindle shape or… read more here.
Keywords: mesenchymal transition; dynamic changes; visualizing dynamic; tgf induced ... See more keywords
TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03398-6
Abstract: Metastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal transition (EMT) is the process in which cells lose epithelial integrity and become motile, a critical step for cancer cell invasion, drug resistance… read more here.
Keywords: mesenchymal transition; metabolic reprogramming; epithelial mesenchymal; tgf induced ... See more keywords
Lobeglitazone attenuates fibrosis in corneal fibroblasts by interrupting TGF-beta-mediated Smad signaling
Sign Up to like & getrecommendations! Published in 2021 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-021-05370-2
Abstract: Transforming growth factor beta 1 (TGF-β1) is an important cytokine released after ocular surface injury to promote wound healing. However, its persistence at the injury site triggers a fibrotic response that leads to corneal scarring… read more here.
Keywords: effect; tgf; tgf induced; corneal fibroblasts ... See more keywords