MGMT-inhibitor in combination with TGF-βRI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells
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DOI: 10.1007/s12094-020-02456-x
Abstract: Background Glioblastoma (GB) remains an incurable and deadly brain malignancy that often proves resistant to upfront treatment with temozolomide. Nevertheless, temozolomide remains the most commonly prescribed FDA-approved chemotherapy for GB. The DNA repair protein methylguanine-DNA… read more here.
Keywords: cdk inhibitor; inhibitor; mgmt inhibitor; tgf inhibitor ... See more keywords
Effects of prolonged treatment of TGF-βR inhibitor SB431542 on radiation-induced signaling in breast cancer cells
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DOI: 10.1080/09553002.2022.2069299
Abstract: Abstract Purpose We have earlier characterized increased TGF-β signaling in radioresistant breast cancer cells. In this study, we wanted to determine the effect of prolonged treatment of TGF-βR inhibitor SB431542 on radiation-induced signaling, viz., genes… read more here.
Keywords: breast; sb431542; treatment; tgf ... See more keywords
Optimal regulation of tumour-associated neutrophils in cancer progression
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DOI: 10.1098/rsos.210705
Abstract: In a tumour microenvironment, tumour-associated neutrophils could display two opposing differential phenotypes: anti-tumour (N1) and pro-tumour (N2) effector cells. Converting N2 to N1 neutrophils provides innovative therapies for cancer treatment. In this study, a mathematical… read more here.
Keywords: cancer; tumour; ifn; tgf inhibitor ... See more keywords
TGF-β Inhibitor SB431542 Promotes the Differentiation of Induced Pluripotent Stem Cells and Embryonic Stem Cells into Mesenchymal-Like Cells
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DOI: 10.1155/2018/7878201
Abstract: Due to their potential for tissue engineering applications and ability to modulate the immune system and reduce inflammation, mesenchymal stem cells (MSCs) have been explored as a promising option for the treatment of chronic diseases… read more here.
Keywords: embryonic stem; differentiation; pluripotent stem; tgf inhibitor ... See more keywords