Design and synthesis of novel tranilast analogs: Docking, antiproliferative evaluation and in-silico screening of TGFβR1 inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104368
Abstract: The discovery of the antiproliferative potential of tranilast prompted additional studies directed at understanding the mechanisms of tranilast action. Its inhibitory effect on cell proliferation depends principally on the capacity of tranilast to interfere with… read more here.
Keywords: design synthesis; novel tranilast; tgf inhibitors; tranilast analogs ... See more keywords
Low Transforming Growth Factor-β Pathway Activity in Cervical Adenocarcinomas
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DOI: 10.3389/fonc.2022.797453
Abstract: Cervical cancer is the fourth most common cancer in women worldwide. Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the most common histological types, with AC patients having worse prognosis. Over the last two decades,… read more here.
Keywords: tgf inhibitors; low transforming; scc; pai ... See more keywords
TGF-β Inhibitors for Therapeutic Management of Kidney Fibrosis
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DOI: 10.3390/ph15121485
Abstract: Kidney fibrosis is a common pathophysiological mechanism of chronic kidney disease (CKD) progression caused by several underlying kidney diseases. Among various contributors to kidney fibrosis, transforming growth factor-β1 (TGF-β1) is the major factor driving fibrosis.… read more here.
Keywords: kidney fibrosis; tgf inhibitors; kidney; management ... See more keywords